メチルクロロイソチアゾリノン

米国FDA 物質登録 · UNII DEL7T5QRPN · 登録名 METHYLCHLOROISOTHIAZOLINONE · 単一の化学物質

出典: 米国FDA 物質識別番号（UNII）

Chloromethylisothiazolinone is a 1,2-thiazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom and a chlorine at C-5. It is a powerful biocide and preservative and is the major active ingredient in the commercial product KathonTM. It has a role as an antimicrobial agent, a xenobiotic and an environmental contaminant. It is an organochlorine compound and a member of 1,2-thiazoles. It is functionally related to a methylisothiazolinone.

出典: PubChem

Methylchloroisothiazolinone is the heterocyclic organic compound that conforms to the formula:

制限

韓国

出典: 韓国食薬処 化粧品規制情報

アルゼンチン · ブラジル

• Maximum concentration permitted at final product : 0.0015% (a mixture in proportions of 3: 1 5-Chloro-2-methyl- isothiazol-3 (2H) -one and 2- Methylisothiazol-3 (2H) -one)

ASEAN

• Maximum authorised concentration in the finished cosmetic product : 0.0015 % (of a mixture in the ratio 3:1 of 5-chloro- 2-methylisothiazol 3(2H)-one and 2-methylisothiazol-3(2H)-one)
• Other limitations and requirements : Rinse-off products

カナダ

• Conditions of Use by product type : (a) Not permitted in leave-on products. (b) Rinse-off products Note: If MI is present in a formulation with Methylisothiazolinone / Methylchloroisothiazolinone (MI/MCI) in combination, the cumulative, total concentration of MI and MI/MCI may not exceed 0.0015%.
• Maximum Concentration Permitted : b) 0.0015%

中国

• 最大配合量 : 0.0015%

欧州連合

• Product Type, body parts : rinse-off products
• Maximum concentration in ready for use preparation : 0.0015% (of a mixture in the ratio 3:1 of 5-Chloro-2-methyl-isothiazol-3(2H)-one and 2-Methylisothiazol-3(2H)-one

韓国の有害物質GHS分類: 危険 · H400 (区分1) · H410 (区分1) · H314 (区分1B) · ほか4件

出典: 韓国 有害物質GHS情報（環境公団）

Restriction V/39

出典: EU CosIng 成分リスト

Reviewed by CIR: Final Report on the Safety Assessment of Methylisothiazolinone and Methylchloroisothiazolinone

出典: 米国CIR 安全性評価

Reviewed by CIR: Ammended Safety Assessment of Methylisothiazolinone and Methylchloroisothiazolinone as Used in Cosmetics

出典: 米国CIR 安全性評価