Ingredient Dictionary

METHYLENE DI-T-BUTYLCRESOL

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) is a diarylmethane.

Definition

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) is a diarylmethane.

Source: PubChem

US FDA substance register · UNII KVM0X4X57B · registered name METHYLENE DI-T-BUTYLCRESOL · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Slows spoilage by oxygenANTIOXIDANT

Safety & regulatory references

Banned: ASEAN · European Union · United Kingdom · 유럽

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1682

Source: EU prohibited substances (Annex II)

More data — names, identifiers, properties, test records, literature

Names & identifiers

METHYLENE DI-T-BUTYLCRESOLINCIPhenol, 2,2′-methylenebis[6-(1,1-dimethylethyl)-4-methyl-Synonym메틸렌다이-t-부틸크레솔Korean label name (MFDS standard)

CAS No.chemical registry number: 119-47-1
EC No.EU chemical inventory number: 204-327-1
DTXSIDUS EPA chemical ID: DTXSID4020870
DTXCIDUS EPA compound ID: DTXCID20870

IUPAC: 2,2'-Methylenebis(6-tert-butyl-4-methylphenol)
Molecular formula: C23H32O2
Molecular weight: 340.507 g/mol

Measured properties

Appearance: Liquid, Dry Powder, Other Solid · Off-white solid, [HSDB]
Melting point: 118-128 °C
Solubility: Soluble in oxygen and aromatic solvents. · Water solubility = 0.02 mg/l.
Density: 1.07-1.10 kg/L
Melting/freezing point: 125 ℃
Vapour pressure: 2.5E-09 ㎜Hg (25℃ (est.))
Water solubility: 0.000002 g/100㎖ (25℃)
Relative density: 1.08
n-Octanol/water partition coefficient (Kow): 6.25
Molecular weight: 340.51

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 42 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Antioxidant28
Heat stabilizer4
Processing aids not otherwise specified4
Catalyst1
Fragrance1
UV stabilizer1
Elasticizer1
Defoamer1

1 other uses

Dispersing agent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 2 eye studies are on record.

Classed as low1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 4 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
SkinSens1
Skin Sensitization · QSAR Predicted
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to