メチルイソチアゾリノン

Methylisothiazolinone is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. It is a powerful biocide and preservative and is the minor active ingredient in the commercial product KathonTM. It has a role as an antimicrobial agent, an antifungal agent and an antifouling biocide.

出典: PubChem

米国FDA 物質登録 · UNII 229D0E1QFA · 登録名 METHYLISOTHIAZOLINONE · 単一の化学物質

出典: 米国FDA 物質識別番号（UNII）

Methylisothiazolinone is the heterocyclic organic compound that conforms to the formula:

制限

韓国

許可された防腐剤

イギリス

出典: カナダ 禁止・制限成分リスト · 韓国食薬処 化粧品規制情報 · ASEAN 化粧品指令 · EU 化粧品規則 · 日本 化粧品基準 · 台湾FDA 化粧品成分 · 英国 化粧品規則

アルゼンチン · ブラジル

• Maximum concentration permitted at final product : 0.0015% (a mixture in proportions of 3: 1 5-Chloro-2-methyl- isothiazol-3 (2H) -one and 2- Methylisothiazol-3 (2H) -one)
• Maximum concentration permitted at final product : 0.01%

ASEAN

• Maximum authorised concentration in the finished cosmetic product : 0.0015 % (of a mixture in the ratio 3:1 of 5-chloro- 2-methylisothiazol 3(2H)-one and 2-methylisothiazol-3(2H)-one)
• Other limitations and requirements : Rinse-off products

カナダ

• Conditions of Use by product type : (a) Not permitted in leave-on products. (b) Rinse-off products Note: If MI is present in a formulation with Methylisothiazolinone / Methylchloroisothiazolinone (MI/MCI) in combination, the cumulative, total concentration of MI and MI/MCI may not exceed 0.0015%.
• Maximum Concentration Permitted : b) 0.0015%

台湾

• 倘前述三國家地區政府管理有差異時，則採其中限量規定方式最安全者。
• ※ 本表所稱之口腔製劑，包含非藥用牙膏、漱口水類及美白牙齒類等化粧品。
• 用途 : 防腐
• 最大配合量 : 立即沖洗產品 : 0.0015%

日本

• 100gあたりの最大配合量 (Cosmetics not used for mucosa and to be washed away) : 0.01 g
• 100gあたりの最大配合量 (Cosmetics not used for mucosa and not to be washed away) : 0.01 g

中国

• 最大配合量 : 0.01%
• 最大配合量 : 0.0015%

欧州連合

• Product Type, body parts : rinse-off products
• Maximum concentration in ready for use preparation : 0.0015% (of a mixture in the ratio 3:1 of 5-Chloro-2-methyl-isothiazol-3(2H)-one and 2-Methylisothiazol-3(2H)-one
• Product Type, body parts : Rinse-off products
• Maximum concentration in ready for use preparation : 0,0015 %

韓国の有害物質GHS分類: 危険 · H301 (区分3) · H330 (区分2) · H314 (区分1B) · ほか4件

出典: 韓国 有害物質GHS情報（環境公団）

EU化粧品規則 附属書V（許可防腐剤） 第57項 · 最大濃度 0,0015 % Rinse-off products

出典: EU 許可防腐剤（附属書V）

Restriction V/57 V/39 · SCCS opinion: Opinion on Methylisothiazolinone (P94) (Sensitisation only) Submission II

出典: EU CosIng 成分リスト

Reviewed by CIR: Final Report on the Safety Assessment of Methylisothiazolinone and Methylchloroisothiazolinone

出典: 米国CIR 安全性評価

Reviewed by CIR: Ammended Safety Assessment of Methylisothiazolinone and Methylchloroisothiazolinone as Used in Cosmetics

出典: 米国CIR 安全性評価

Reviewed by CIR: Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

出典: 米国CIR 安全性評価

Reviewed by CIR: Final Report of the Safety Assessment of Methylisothiazolinone

出典: 米国CIR 安全性評価