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Ingredient Dictionary

METHYLISOTHIAZOLINONE

Methylisothiazolinone is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom.

Korean limit
0.0015%
Molecular structure

How much products actually contain

No product states its amount yet.

Of the products containing it, 4 list it before the 1% line and 74 after it (usually 1% or less).

Products using this ingredient

12 of 78 confirmed · likeliest to carry enough first · See all 78

Definition

Methylisothiazolinone is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. It is a powerful biocide and preservative and is the minor active ingredient in the commercial product KathonTM. It has a role as an antimicrobial agent, an antifungal agent and an antifouling biocide.

Source: PubChem

US FDA substance register · UNII 229D0E1QFA · registered name METHYLISOTHIAZOLINONE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Methylisothiazolinone is the heterocyclic organic compound that conforms to the formula:

Cosmetic roles

Stops microbes growing in the productPRESERVATIVE

Safety & regulatory references

Restricted
South Korea · Taiwan
Allowed preservative
Taiwan · United Kingdom

Source: Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information · ASEAN Cosmetic Directive · EU Cosmetics Regulation · Japan Standards for Cosmetics · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Argentina · Brazil

  • Maximum concentration permitted at final product : 0.0015% (a mixture in proportions of 3: 1 5-Chloro-2-methyl- isothiazol-3 (2H) -one and 2- Methylisothiazol-3 (2H) -one)
  • Maximum concentration permitted at final product : 0.01%

ASEAN

  • Maximum authorised concentration in the finished cosmetic product : 0.0015 % (of a mixture in the ratio 3:1 of 5-chloro- 2-methylisothiazol 3(2H)-one and 2-methylisothiazol-3(2H)-one)
  • Other limitations and requirements : Rinse-off products

Canada

  • Conditions of Use by product type : (a) Not permitted in leave-on products. (b) Rinse-off products Note: If MI is present in a formulation with Methylisothiazolinone / Methylchloroisothiazolinone (MI/MCI) in combination, the cumulative, total concentration of MI and MI/MCI may not exceed 0.0015%.
  • Maximum Concentration Permitted : b) 0.0015%

Japan

  • Maximum amount per 100 g (Cosmetics not used for mucosa and to be washed away) : 0.01 g
  • Maximum amount per 100 g (Cosmetics not used for mucosa and not to be washed away) : 0.01 g

China

  • Maximum concentration : 0.01%
  • Maximum concentration : 0.0015%

European Union

  • Product Type, body parts : rinse-off products
  • Maximum concentration in ready for use preparation : 0.0015% (of a mixture in the ratio 3:1 of 5-Chloro-2-methyl-isothiazol-3(2H)-one and 2-Methylisothiazol-3(2H)-one
  • Product Type, body parts : Rinse-off products
  • Maximum concentration in ready for use preparation : 0,0015 %

Source: MFDS (Korea) cosmetic regulatory information

Korea’s toxic-substance GHS classification: Danger · H301 (category 3) · H330 (category 2) · H314 (category 1B) · +4 more

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex V (allowed preservatives), entry 57 · maximum concentration 0,0015 % Rinse-off products

Source: EU allowed preservatives (Annex V)

Restriction V/57 V/39 · SCCS opinion: Opinion on Methylisothiazolinone (P94) (Sensitisation only) Submission II

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report on the Safety Assessment of Methylisothiazolinone and Methylchloroisothiazolinone

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Ammended Safety Assessment of Methylisothiazolinone and Methylchloroisothiazolinone as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report of the Safety Assessment of Methylisothiazolinone

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name メチルイソチアゾリノン: 本品は、次の化学式で表される複素環式化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

METHYLISOTHIAZOLINONEINCI메칠이소치아졸리논Korean label name (MFDS standard)3(2H)-Isothiazolone, 2-methyl-SynonymMETHYL ISOTHIAZOLINONESynonymメチルイソチアゾリノンJapanese labelling name
CAS No.chemical registry number
2682-20-4
EC No.EU chemical inventory number
220-239-6
DTXSIDUS EPA chemical ID
DTXSID2034259
DTXCIDUS EPA compound ID
DTXCID0014259
IUPAC
2-Methyl-1,2-thiazol-3(2H)-one
Molecular formula
C4H5NOS
Molecular weight
115.15 g/mol

Measured properties

Appearance
Liquid · Colorless solid, [Merck Index] Dark yellow powder with lumps, [Sigma-Aldrich MSDS]
Boiling point
BP: 93 °C at 0.03 mm Hg
Melting point
50-51 °C
Solubility
Solubility in: acetonitrile 78.6, methanol 79.1, hexane 2.371, xylenol 15.65 (g/100 mL)
Density
1.35 g/mL at 25 °C · Commercial product is supplied as a clear, light amber liquid, freezing point -18 °C to -21.5 °C, density 1.19 at 20 °C/4 °C, viscosity (23 °C): 5.0 cP. Readily miscible in water, lower alcohols, glycols, other hydrophilic organic solvents. Insoluble in petrolatum /Mixture with methylchloroisothiazolinone/
Stability
Stable under recommended storage conditions.
Dissociation constant
Does not dissociate
Colour
white
Melting/freezing point
48~50 ℃
Initial boiling point and range
93 ℃
Flash point
64.3 ℃
Vapour pressure
0.0073 hPa(25℃)
Water solubility
&amp, gt, 4200 g/ℓ (20 ℃)
Relative density
1.39
n-Octanol/water partition coefficient (Kow)
-0.71
Molecular weight
115.15

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 970 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

  • Preservative942
  • Biocide10
  • Processing aids not otherwise specified4
  • Surfactant (surface active agent)3
  • Fragrance1
  • Antioxidant1
  • Brightener1
  • Surface modifier1
7 other uses
  • Anti-adhesive/cohesive1
  • Soil amendments1
  • UV stabilizer1
  • Cleaning agent1
  • Viscosity modifier1
  • Sizing agent1
  • Adhesion/cohesion promoter1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

6 skin studies and 1 eye studies are on record.

Classed as highly irritating2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 7 studies
  • Category 8.2B (Category 1B)
    Skin Irritation · Read Across
  • Category 6.5B (Category 1)
    Skin Sensitization · Read Across
  • SkinSens1
    Skin Sensitization · QSAR Predicted
  • Sh
    Skin Sensitization · Authoritative
  • Skin sensitisation - category 1
    Skin Sensitization · Screening
  • Skin corrosion - category 1B
    Skin Irritation · Screening
  • Category 8.3A (Category 1)
    Eye Irritation · Read Across

Source: US EPA CompTox dashboard

Related literature

Linked databases 30

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