METHYLISOTHIAZOLINONE

Methylisothiazolinone is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. It is a powerful biocide and preservative and is the minor active ingredient in the commercial product KathonTM. It has a role as an antimicrobial agent, an antifungal agent and an antifouling biocide.

Fuente: PubChem

Registro de sustancias de la FDA (EE. UU.) · UNII 229D0E1QFA · nombre registrado METHYLISOTHIAZOLINONE · sustancia química única

Fuente: Identificador único de ingredientes de la FDA (UNII)

Methylisothiazolinone is the heterocyclic organic compound that conforms to the formula:

Restringido

Corea del Sur · Taiwán

Conservante permitido

Reino Unido · Taiwán

Fuente: Lista de ingredientes restringidos de Health Canada · Información regulatoria cosmética del MFDS (Corea) · Directiva cosmética de la ASEAN · Reglamento de cosméticos de la UE · Normas de cosméticos de Japón · Ingredientes cosméticos de la FDA de Taiwán · Normativa cosmética del Reino Unido (OPSS)

Argentina · Brasil

• Maximum concentration permitted at final product : 0.0015% (a mixture in proportions of 3: 1 5-Chloro-2-methyl- isothiazol-3 (2H) -one and 2- Methylisothiazol-3 (2H) -one)
• Maximum concentration permitted at final product : 0.01%

ASEAN

• Maximum authorised concentration in the finished cosmetic product : 0.0015 % (of a mixture in the ratio 3:1 of 5-chloro- 2-methylisothiazol 3(2H)-one and 2-methylisothiazol-3(2H)-one)
• Other limitations and requirements : Rinse-off products

Canadá

• Conditions of Use by product type : (a) Not permitted in leave-on products. (b) Rinse-off products Note: If MI is present in a formulation with Methylisothiazolinone / Methylchloroisothiazolinone (MI/MCI) in combination, the cumulative, total concentration of MI and MI/MCI may not exceed 0.0015%.
• Maximum Concentration Permitted : b) 0.0015%

Japón

• Cantidad máxima por 100 g (Cosmetics not used for mucosa and to be washed away) : 0.01 g
• Cantidad máxima por 100 g (Cosmetics not used for mucosa and not to be washed away) : 0.01 g

China

• Concentración máxima : 0.01%
• Concentración máxima : 0.0015%

Unión Europea

• Product Type, body parts : rinse-off products
• Maximum concentration in ready for use preparation : 0.0015% (of a mixture in the ratio 3:1 of 5-Chloro-2-methyl-isothiazol-3(2H)-one and 2-Methylisothiazol-3(2H)-one
• Product Type, body parts : Rinse-off products
• Maximum concentration in ready for use preparation : 0,0015 %

Clasificación GHS de sustancias tóxicas de Corea: Peligro · H301 (categoría 3) · H330 (categoría 2) · H314 (categoría 1B) · y 4 más

Fuente: Registro GHS de sustancias tóxicas de Corea (NIER)

Reglamento de cosméticos de la UE, anexo V (conservantes permitidos), entrada 57 · concentración máxima 0,0015 % Rinse-off products

Fuente: Conservantes permitidos UE (anexo V)

Restriction V/57 V/39 · SCCS opinion: Opinion on Methylisothiazolinone (P94) (Sensitisation only) Submission II

Fuente: Lista de ingredientes CosIng (UE)

Reviewed by CIR: Final Report on the Safety Assessment of Methylisothiazolinone and Methylchloroisothiazolinone

Fuente: Cosmetic Ingredient Review (CIR, EE. UU.)

Reviewed by CIR: Ammended Safety Assessment of Methylisothiazolinone and Methylchloroisothiazolinone as Used in Cosmetics

Fuente: Cosmetic Ingredient Review (CIR, EE. UU.)

Reviewed by CIR: Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

Fuente: Cosmetic Ingredient Review (CIR, EE. UU.)

Reviewed by CIR: Final Report of the Safety Assessment of Methylisothiazolinone

Fuente: Cosmetic Ingredient Review (CIR, EE. UU.)