METHYLISOTHIAZOLINONE

Methylisothiazolinone is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. It is a powerful biocide and preservative and is the minor active ingredient in the commercial product KathonTM. It has a role as an antimicrobial agent, an antifungal agent and an antifouling biocide.

来源: PubChem

美国FDA 物质登记 · UNII 229D0E1QFA · 登记名称 METHYLISOTHIAZOLINONE · 单一化学物质

来源: 美国FDA 物质识别码（UNII）

Methylisothiazolinone is the heterocyclic organic compound that conforms to the formula:

限用

韩国

准用防腐剂

英国

来源: 加拿大禁用·限用成分清单 · 韩国食药处 化妆品法规信息 · 东盟化妆品指令 · 欧盟化妆品法规 · 日本化妆品标准 · 台湾FDA 化妆品成分 · 英国化妆品法规

阿根廷 · 巴西

• Maximum concentration permitted at final product : 0.0015% (a mixture in proportions of 3: 1 5-Chloro-2-methyl- isothiazol-3 (2H) -one and 2- Methylisothiazol-3 (2H) -one)
• Maximum concentration permitted at final product : 0.01%

东盟

• Maximum authorised concentration in the finished cosmetic product : 0.0015 % (of a mixture in the ratio 3:1 of 5-chloro- 2-methylisothiazol 3(2H)-one and 2-methylisothiazol-3(2H)-one)
• Other limitations and requirements : Rinse-off products

加拿大

• Conditions of Use by product type : (a) Not permitted in leave-on products. (b) Rinse-off products Note: If MI is present in a formulation with Methylisothiazolinone / Methylchloroisothiazolinone (MI/MCI) in combination, the cumulative, total concentration of MI and MI/MCI may not exceed 0.0015%.
• Maximum Concentration Permitted : b) 0.0015%

台湾

• 倘前述三國家地區政府管理有差異時，則採其中限量規定方式最安全者。
• ※ 本表所稱之口腔製劑，包含非藥用牙膏、漱口水類及美白牙齒類等化粧品。
• 用途 : 防腐
• 最大配合量 : 立即沖洗產品 : 0.0015%

日本

• 每100g最大配合量 (Cosmetics not used for mucosa and to be washed away) : 0.01 g
• 每100g最大配合量 (Cosmetics not used for mucosa and not to be washed away) : 0.01 g

中国

• 最大配合量 : 0.01%
• 最大配合量 : 0.0015%

欧盟

• Product Type, body parts : rinse-off products
• Maximum concentration in ready for use preparation : 0.0015% (of a mixture in the ratio 3:1 of 5-Chloro-2-methyl-isothiazol-3(2H)-one and 2-Methylisothiazol-3(2H)-one
• Product Type, body parts : Rinse-off products
• Maximum concentration in ready for use preparation : 0,0015 %

韩国有毒物质 GHS 分类: 危险 · H301 (第3类) · H330 (第2类) · H314 (第1B类) · 另有 4 项

来源: 韩国有毒物质 GHS 信息（环境公团）

欧盟化妆品法规 附录V（准用防腐剂） 第57项 · 最高浓度 0,0015 % Rinse-off products

来源: 欧盟准用防腐剂（附录V）

Restriction V/57 V/39 · SCCS opinion: Opinion on Methylisothiazolinone (P94) (Sensitisation only) Submission II

来源: 欧盟 CosIng 成分清单

Reviewed by CIR: Final Report on the Safety Assessment of Methylisothiazolinone and Methylchloroisothiazolinone

来源: 美国CIR 安全性评估

Reviewed by CIR: Ammended Safety Assessment of Methylisothiazolinone and Methylchloroisothiazolinone as Used in Cosmetics

来源: 美国CIR 安全性评估

Reviewed by CIR: Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

来源: 美国CIR 安全性评估

Reviewed by CIR: Final Report of the Safety Assessment of Methylisothiazolinone

来源: 美国CIR 安全性评估