METHYLPARABEN

Methylparaben is the ester of methyl alcohol and p-hydroxybenzoic acid. It conforms to the formula:

Methylparaben is a 4-hydroxybenzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with methanol. It is the most frequently used antimicrobial preservative in cosmetics. It occurs naturally in several fruits, particularly in blueberries. It has a role as an antifungal agent, a neuroprotective agent, an antimicrobial food preservative and a plant metabolite.

来源: PubChem

美国FDA 物质登记 · UNII A2I8C7HI9T · 登记名称 Methylparaben · 单一化学物质

来源: 美国FDA 物质识别码（UNII）

限用

韩国 · 中国

来源: 韩国食药处 化妆品法规信息

阿根廷 · 巴西

• Maximum concentration permitted at final product : (a) 0,4% (expresso como ácido) para cada substância considerada em forma individual. (b) 0,8% (expresso como ácido) para a soma das concentrações individuais de ácido 4-p-hidroxibenzóico, seus ésteres de metil e etil e seus sais contidos no produto.
• Other limitations and requirements : Prohibit: isopropylparaben, isobutylparaben, fenylparaben, benzylparaben, pentylparaben.

东盟

• Maximum authorised concentration in the finished cosmetic product : 0.4% (as acid) for single ester 0.8% (as acid) for mixtures of esters

台湾

• 倘前述三國家地區政府管理有差異時，則採其中限量規定方式最安全者。
• ※ 本表所稱之口腔製劑，包含非藥用牙膏、漱口水類及美白牙齒類等化粧品。
• 用途 : 防腐
• 最大配合量 : (a) 0.4% (以 acid 計，單獨使用)
• (b) 0.8% (以 acid 計，混合使用)
• (a) 0.4%
• (b) 0.8%

日本

• 每100g最大配合量(Maximum amount of ingredient per 100 g) : 1.0 as total(合計量として1.0)

欧盟

• Maximum concentration in ready for use preparation : 0,4% (as acid) for single ester 0,8% (as acid) for mixtures of esters

未列入韩国有毒物质 GHS 分类 · 现有化学物质

来源: 韩国有毒物质 GHS 信息（环境公团）

Restriction V/12 · Other restriction: ban substances that deplete the ozone layer · SCCS opinion: Extended Opinion on the Safety Evaluation of Parabens; Opinion concerning Restrictions on Materials listed in annex VI of Directive 76/768/EEC on Cosmetic Products; Opinion on Parabens; Opinion on Parabens updated request for a scientific opinion on 'propyl-and butylparaben'; Opinion on Parabens, underarm cosmetics and breast cancer

来源: 欧盟 CosIng 成分清单

Reviewed by CIR: Final Amended Report on the Safety Assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben and Benzylparaben as used in cosmetic products

来源: 美国CIR 安全性评估

Reviewed by CIR: Amended Safety Assessment of Parabens as Used in Cosmetics

来源: 美国CIR 安全性评估

Reviewed by CIR: Final Report on the Safety Assessment of Methylparaben, Ethylparaben, Propylparaben, and Butylparaben

来源: 美国CIR 安全性评估