What is this ingredient?

미국 FDA 물질 등록 · UNII 722CLJ6H6K · 등록명 2-Methyl-4'-(methylthio)-2-morpholinopropiophenone · 단일 화학물질

Ingredient Dictionary

METHYLTHIOPHENYL MORPHOLINO ISOBUTANONE

Definition

US FDA substance register · UNII 722CLJ6H6K · registered name 2-Methyl-4'-(methylthio)-2-morpholinopropiophenone · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Methylthiophenyl Morpholino Isobutanone is the organic compound that conforms to the formula:

Cosmetic roles

Holds powders togetherBINDING

Safety & regulatory references

Banned: ASEAN · European Union · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1592

Source: EU prohibited substances (Annex II)

Restriction II/1592

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

METHYLTHIOPHENYL MORPHOLINO ISOBUTANONEINCI1-Propanone, 2-methyl-1-[4-(methylthio)phenyl]-2-(4-morpholinyl)-Synonym

CAS No.chemical registry number: 71868-10-5
EC No.EU chemical inventory number: 400-600-6
DTXSIDUS EPA chemical ID: DTXSID8038857
DTXCIDUS EPA compound ID: DTXCID6018857

IUPAC: 2-Methyl-1-[4-(methylsulfanyl)phenyl]-2-(morpholin-4-yl)propan-1-one
Molecular formula: C15H21NO2S
Molecular weight: 279.4 g/mol

What products actually use it for

What the 18 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Photosensitizers12
Processing aids not otherwise specified3
Photosensitive agent2
Binder1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

8 skin studies and 4 eye studies are on record.

Classed as low7

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 12 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: OECD 404 according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: US EPA s 163.81-5 "Primary dermal irritation study". Federal Register, Vol. 43, No. 163, August 22, 1978. according to
Classification not possible
Skin Irritation · Screening
Not likely to be sensitizing
skin sensitisation · Screening · according to other guideline: 79/831/EEC, Annex V, part B.417 (maximisation test)
Not likely to be sensitizing
skin sensitisation · Screening · according to other guideline: 79/831/EEC, Annex V, part B. 417 (maximisation test)
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) modified
Classification not possible
Skin Sensitization · Screening
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: OECD 405 according to
Classification not possible
Eye Irritation · Screening
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: EPA, s 163.81-4 "Primary eye irritation study". Federal Register, Vol. 43, No. 163, August 22, 1978. according to