Definition
US FDA substance register · UNII 0HI0D71MCI · registered name METHYLTRIMETHOXYSILANE · single chemical substance
Silane, Trimethoxymethyl-
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 1185-55-3
- EC No.EU chemical inventory number
- 214-685-0
- DTXSIDUS EPA chemical ID
- DTXSID3027370
- DTXCIDUS EPA compound ID
- DTXCID407370
- IUPAC
- Trimethoxy(methyl)silane
- Molecular formula
- C4H12O3Si
- Molecular weight
- 136.222 g/mol
Measured properties
- Appearance
- Liquid, Other Solid, CBI · Colorless liquid, [Sigma-Aldrich MSDS]
- Boiling point
- 103.5 °C @760 [mm Hg]
- Density
- 0.949 @ 20°C
- Melting/freezing point
- 11 ℃
- Initial boiling point and range
- 102 ℃
- Flash point
- 0 ℃
- Upper/lower flammability or explosive limits
- 12.5 / 2.2 %
- Vapour pressure
- 30 ㎜Hg (at 20C)
- Vapour density
- 4.7 ()
- Relative density
- 0.951 (at 25C)
- n-Octanol/water partition coefficient (Kow)
- -0.67 ((est.))
- Auto-ignition temperature
- 225 ℃
- Molecular weight
- 136.22
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 33 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Dehydrating agent (desiccant)10
- Chemical reaction regulator6
- Adhesion/cohesion promoter4
- Hardener4
- Processing aids not otherwise specified2
- Binder2
- Monomers1
- Dispersing agent1
3 other uses
- Intermediate1
- Sealant (barrier)1
- Film former1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
9 skin studies and 4 eye studies are on record.
The studies disagree (the most common conclusion covers 13%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 13 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Not classified
Skin Irritation · Screening - Classification not possible
Skin Sensitization · Screening - Category 6.3B (Category 3)
Skin Irritation · Read Across - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EPA OPPTS 870.2600 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation) - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EPA OTS 798.4100 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation) - Category 2B
Eye Irritation · Screening - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Source: US EPA CompTox dashboard
Related literature
Linked databases 15
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English