Minoxidil is a pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6.
Definition
US FDA substance register · UNII 5965120SH1 · registered name MINOXIDIL · single chemical substance
Minoxidil is a pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6. It has a role as a vasodilator agent and an antihypertensive agent. It is a member of piperidines, an aminopyrimidine and a pyrimidine N-oxide.
Source: PubChem
Minoxidil is the heterocyclic compound that conforms to the formula
Cosmetic roles
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea · Taiwan · United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex II (prohibited substances), entry 372
Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics
Restriction II/372
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 38304-91-5
- EC No.EU chemical inventory number
- 253-874-2
- DTXSIDUS EPA chemical ID
- DTXSID9040685
- DTXCIDUS EPA compound ID
- DTXCID7020685
- IUPAC
- 1-Oxo-4-(piperidin-1-yl)-1lambda~5~-pyrimidine-2,6-diamine
- Molecular formula
- C9H15N5O
- Molecular weight
- 209.253 g/mol
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner1
- Hair fixative (EPA)1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- Category 6.5B (Category 1)
Skin Sensitization · Read Across - Category 6.3A (Category 2)
Skin Irritation · Read Across - SkinSens1
Skin Sensitization · QSAR Predicted - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- Minoxidil sulfotransferase enzymatical activity in plants: A novel paradigm in increasing minoxidil response in androgenetic alopecia · 2023
- Minoxidil: a comprehensive review · 2021
- Comparative study of efficacy of topical minoxidil versus topical minoxidil with finasteride in androgenetic alopecia · 2021
- Contact dermatitis to minoxidil · 2020
- Minoxidil · 2020
Linked databases 21
- ASEAN Cosmetic Directive
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU prohibited substances (Annex II)
- Health Canada Cosmetic Ingredient Hotlist
- Korea toxic substances GHS register (NIER)
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem
- Taiwan FDA cosmetic ingredients
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese