Definition
US FDA substance register · UNII GF3CGH8D7Z · registered name Cresol · mixture
Cosmetic roles
Safety & regulatory references
- Banned
- Canada
Source: Health Canada Cosmetic Ingredient Hotlist
Japan
- Maximum amount per 100 g (Cosmetics not used for mucosa and to be washed away) : 0.010 g
- Maximum amount per 100 g (Cosmetics not used for mucosa and not to be washed away) : 0.010 g
Source: MFDS (Korea) cosmetic regulatory information
Korea’s toxic-substance GHS classification: Danger · H311 (category 3) · H301 (category 3) · H314 (category 1)
Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics
Reviewed by CIR: Final Report on the Safety Assessment of Sodium p-Chloro-m-Cresol, p-Chloro-m-Cresol, Chlorothymol, Mixed Cresols, m-Cresol, o-Cresol, p-Cresol, Isopropyl Cresols, Thymol, o-Cymen-5-ol and Carvacrol
CIR reviewed this ingredient and flagged its status as: Insufficient data ingredients with no uses reported to FDA's Voluntary Cosmetic Registration Program (VCRP) (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name クレゾール: 本品は、オルトクレゾール、メタクレゾール及びパラクレゾールの混合物である。
Source: JCIA labelling names (Japan)
JCIA labelling name 混合クレゾール: 本品は、ｏ－クレゾール、ｍ－クレゾール及びｐ－クレゾールの混合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 1319-77-3
- EC No.EU chemical inventory number
- 215-293-2
- DTXSIDUS EPA chemical ID
- DTXSID3024364
- DTXCIDUS EPA compound ID
- DTXCID601323289
- Molecular formula
- C7H8O
Measured properties
- Appearance
- liquid
- Melting/freezing point
- -18.9 ℃(35℃, ASTm D6875-08)
- Initial boiling point and range
- 191~203 ℃
- Flash point
- 93 ℃
- Vapour pressure
- (0.11-1.299 mmHg, 25℃)
- Water solubility
- 23.3 g/ℓ(g/L, 20℃ (OECD TG105))
- Vapour density
- 3.72
- Relative density
- 1.03 (25℃)
- n-Octanol/water partition coefficient (Kow)
- 2.33 (OECD TG117)
- Auto-ignition temperature
- (&, gt, 580 ℃, DIN 51794)
- Decomposition temperature
- (-3696 to -3706kJ/mol)
- Viscosity
- (14.1 mPa s at 20 °C dynamic)
- Molecular weight
- 108.14
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 11 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance3
- Biocide2
- Solvent2
- Antioxidant1
- Chemical reaction regulator1
- Elasticizer1
- UV stabilizer1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
7 skin studies and 3 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 10 studies
- Category 1
Skin Irritation · Screening - Classification not possible
Skin Sensitization · Screening - Skin Corr. 1B
Skin Irritation · Screening - Skin corrosion/irritation - Category 1
Skin Irritation · Screening - Category 8.2B (Category 1B)
Skin Irritation · Read Across - Skin Corr. 1B
Skin Irritation · Authoritative - Skin corrosion - category 1A
Skin Irritation · Screening - Category 8.3A (Category 1)
Eye Irritation · Read Across - Category 1
Eye Irritation · Screening - Eye Dam. 1
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- Acute respiratory distress syndrome following cutaneous exposure to Lysol: a case report. · 1999
- Final Report on the Safety Assessment of Sodium p -Chloro- m -Cresol, p -Chloro- m -Cresol, Chlorothymol, Mixed Cresols, m -Cresol, o -Cresol, p -Cresol, Isopropyl Cresols, Thymol, o -Cymen-5-ol, and Carvacrol1 · 2006
Linked databases 22
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- Health Canada Cosmetic Ingredient Hotlist
- Japan Standards for Cosmetics
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- Tlooto literature search 2
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- US National Toxicology Program reports
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese