Ingredient Dictionary

MORPHOLINOPROPANE SULFONIC ACID

3-(N-morpholino)propanesulfonic acid is a Good's buffer substance, pKa = 7.2 at 20 C.

Definition

3-(N-morpholino)propanesulfonic acid is a Good's buffer substance, pKa = 7.2 at 20 C. It is an organosulfonic acid, a member of morpholines and a MOPS. It is a conjugate acid of a 3-(N-morpholino)propanesulfonate. It is a tautomer of a 3-(N-morpholiniumyl)propanesulfonate.

Source: PubChem

US FDA substance register · UNII 273BP63NV3 · registered name 3-(N-MORPHOLINO)PROPANESULFONIC ACID · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Lightens hair or skinBLEACHINGKeeps pH steadyBUFFERING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Names & identifiers

MORPHOLINOPROPANE SULFONIC ACIDINCI4-Morpholinepropanesulfonic acidSynonym

CAS No.chemical registry number: 1132-61-2
EC No.EU chemical inventory number: 214-478-5
DTXSIDUS EPA chemical ID: DTXSID4044371
DTXCIDUS EPA compound ID: DTXCID2024371

IUPAC: 3-(Morpholin-4-yl)propane-1-sulfonic acid
Molecular formula: C7H15NO4S
Molecular weight: 209.26 g/mol

Measured properties

Appearance: White solid, [Merck Index] White odorless powder, [Caledon Laboratories MSDS] · solid
Colour: white
Melting/freezing point: 281.6 ℃
Initial boiling point and range: 354.59 ℃
Flammability (solid, gas): not flammable
Vapour pressure: 0 ㎩ (25 °C)
Water solubility: 597700 ㎎/ℓ
Relative density: 1.427 g/cm³
n-Octanol/water partition coefficient (Kow): &amp, lt, -2.94
Auto-ignition temperature: &amp, gt, 400 ℃
Molecular weight: 209.264

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

pH regulating agent1
Bleaching agent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

5 skin studies and 2 eye studies are on record.

Classed as low3

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 7 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation)
SkinIrr2
Skin Irritation · QSAR Predicted
SkinSens1
Skin Sensitization · QSAR Predicted
Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to