4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone is an aromatic ketone.
Definition
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone is an aromatic ketone.
Source: PubChem
US FDA substance register · UNII 483V3E1L6J · registered name MUSK KETONE · single chemical substance
Cosmetic roles
Safety & regulatory references
- Restricted
- China · International fragrance standard (IFRA) · South Korea · United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · IFRA fragrance standards · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)
Argentina · Brazil
- Field of application and/or use : All products, except for products for oral hygiene
- Maximum concentration permitted at final product : a) 1.4% in fine fragrances. b) 0.56% in eau de toilette c) 0,042% in other products
ASEAN
- Field of application and/or use : All cosmetic products, with the exception of oral care products
- Maximum authorised concentration in the finished cosmetic product : (a) 1.4 % in fine fragrance (b) 0.56 % in eau de toilette (c) 0.042 % in other products
European Union
- Product Type, body parts : All cosmetic products, with the exception of oral care products
- Maximum concentration in ready for use preparation : (a) 1.4% in fine fragrance (b) 0.56% in eau de toilette (c) 0.042% in other products
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex III (restricted substances), entry 97 · maximum concentration (a) 1.4% in fine fragrance (b) 0.56% in eau de toilette (c) 0.042% in other products · applies to All cosmetic products, with the exception of oral care products
Restriction III/97
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ムスクケトン: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 81-14-1
- EC No.EU chemical inventory number
- 201-328-9
- DTXSIDUS EPA chemical ID
- DTXSID6025690
- DTXCIDUS EPA compound ID
- DTXCID405690
- IUPAC
- 1-(4-tert-Butyl-2,6-dimethyl-3,5-dinitrophenyl)ethan-1-one
- Molecular formula
- C14H18N2O5
- Molecular weight
- 294.307 g/mol
Measured properties
- Appearance
- Musk ketone is a light yellow crystalline solid. Insoluble in water. (NTP, 1992) · Liquid
- Odour
- Sweet, very persistent, slightly animal musk odor · Unique ... powdery
- Melting point
- 274.1 to 277.7 °F (NTP, 1992) · 135.5 °C
- Solubility
- Insoluble (<1 mg/ml at 68.0 °F) (NTP, 1992) · In water, 0.46 mg/L at 25 °C
- Density
- Relative density: 0.73 g/cu cm
- Stability
- Stable under recommended storage conditions.
- Melting/freezing point
- 135~137 ℃
- Initial boiling point and range
- 395 ℃
- Flash point
- &, gt, 168 ℃
- Vapour pressure
- 0.00004 ㎩
- Relative density
- 0.73
- n-Octanol/water partition coefficient (Kow)
- 4.3
- Molecular weight
- 294.3
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 14 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance12
- Flavouring and nutrient1
- Deodorizer1
Source: US EPA CompTox dashboard
Related literature
- Assessment of dermal exposures for synthetic musks from personal care products in Taiwan. · 2019
- Industrial, residential, and treated effluents contribute to synthetic musk pollution in Australian waterways. · 2026
- Estrogenic Activity of Cosmetic Components in Reporter Cell Lines: Parabens, UV Screens, and Musks · 2005
- Photoallergic potential in the guinea‐pig of the nitromusk perfume ingredients musk ambrette, musk moskene, musk xylene, musk ketone, and musk tibetene · 1988
- Phototoxicity, photoallergy, and contact sensitization of nitro musk perfume raw materials · 1986
Linked databases 27
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU restricted substances (Annex III)
- EU SCCS safety opinions
- IFRA fragrance standards
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese