Musk xylene is a C-nitro compound that is m-xylene bearing three nitro substituents at positions 2, 4 and 6 as well as a tert-butyl group at position 5.
定义
Musk xylene is a C-nitro compound that is m-xylene bearing three nitro substituents at positions 2, 4 and 6 as well as a tert-butyl group at position 5. It has a role as a fragrance, a carcinogenic agent and an explosive. It is functionally related to a m-xylene and a 1,3,5-trinitrobenzene.
来源: PubChem
美国FDA 物质登记 · UNII 1ZAO16GU5K · 登记名称 MUSK XYLENE · 单一化学物质
化妆品中的作用
安全与法规参考
- 禁用
- 国际香料标准(IFRA)
- 限用
- 韩国 · 英国 · 中国
来源: IFRA 香料标准 · 东盟化妆品指令 · 欧盟化妆品法规 · 韩国食药处 化妆品法规信息 · 英国化妆品法规
阿根廷 · 巴西
- Field of application and/or use : All products, except for products for oral hygiene
- Maximum concentration permitted at final product : a) 1% in fine fragrances. b) 0,4% in eau de toilette c) 0.03% other products
东盟
- Field of application and/or use : All cosmetic products, with the exception of oral care products
- Maximum authorised concentration in the finished cosmetic product : (a) 1.0 % in fine fragrance (b) 0.4 % in eau de toilette (c) 0.03 % in other products
欧盟
- Product Type, body parts : All cosmetic products, with the exception of oral products
- Maximum concentration in ready for use preparation : (a) 1.0% in fine fragrance (b) 0.4% in eau de toilette (c) 0.03% in other products
来源: 韩国食药处 化妆品法规信息
未列入韩国有毒物质 GHS 分类 · 现有化学物质 · 重点管理物质
欧盟化妆品法规 附录III(限用物质) 第96项 · 最高浓度 (a) 1.0% in fine fragrance (b) 0.4% in eau de toilette (c) 0.03% in other products · 适用 All cosmetic products, with the exception of oral products Note: 'Due to environmental concerns, musk xylene is included in the authorisation list (Annex IV) of REACH. Musk xylene cannot be placed on the market or used unless authorisation has been granted under REACH’
来源: 欧盟限用成分(附录III)
Restriction III/96 Note: 'Due to environmental concerns, musk xylene is included in the authorisation list (Annex IV) of REACH. Musk xylene cannot be placed on the market or used unless authorisation has been granted under REACH’. · Other restriction: ban substances that deplete the ozone layer
来源: 欧盟 CosIng 成分清单
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
- CAS No.化学物质登记号
- 81-15-2
- EC No.欧盟化学品目录编号
- 201-329-4
- DTXSID美国EPA化学品编号
- DTXSID1021405
- DTXCID美国EPA化合物编号
- DTXCID901405
- IUPAC
- 1-tert-Butyl-3,5-dimethyl-2,4,6-trinitrobenzene
- 分子式
- C12H15N3O6
- 分子量
- 297.267 g/mol
实测物性
- 性状
- 5-tert-Butyl-2,4,6-trinitro-m-xylene is a white to light-colored crystalline solid. It is insoluble in water and denser than water. Hence sinks in water. Contact may irritate skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals. · Plates, needles from alcohol
- 气味
- Strong musk odor · Sweet, musky odor
- 熔点
- 111.5 °C
- 溶解性
- In water, 0.15 mg/L at 22 °C · In water, 0.49 mg/L at 25 °C
- 密度
- 0.77 g/cu cm
- 熔点/凝固点
- 110 ℃
- 蒸气压
- 0.000000635 ㎜Hg (at 25℃)
- 溶解度
- 0.472 ㎎/ℓ (at 25℃ (估算值))
- 正辛醇/水分配系数(Kow)
- 4.45
- 分子量
- 297.27
这是对物质本身测得的数值。韩国安全保健公团(KOSHA)的资料仅供编写和审核安全数据表参考,并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
刺激与致敏试验记录
记录有皮肤试验 2 项、眼部试验 1 项。
试验结论基本一致(100%)。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。
查看全部 3 项试验
- Not classified
Skin Sensitization · Screening - Classification not possible
Skin Irritation · Screening - Category 2B
Eye Irritation · Screening
来源: 美国EPA CompTox
相关文献
- Molecular dynamic simulation reveals the molecular interactions of epidermal growth factor receptor with musk xylene are involved in the carcinogenicity · 2023
- Synthesis of Deuterated Surrogate Standards for the Analysis of Legally Regulated Substances in Cosmetics · 2020
- [Determination of 27 fragrances in cosmetics and perfume raw materials by gas chromatography-mass spectrometry]. · 2019
- Photoallergic potential in the guinea‐pig of the nitromusk perfume ingredients musk ambrette, musk moskene, musk xylene, musk ketone, and musk tibetene · 1988
- SPECTROSCOPIC STUDIES OF CUTANEOUS PHOTOSENSITIZING AGENTS—VI. IDENTIFICATION OF THE FREE RADICALS GENERATED DURING THE PHOTOLYSIS OF MUSK AMBRETTE, MUSK XYLENE AND MUSK KETONE · 1983
关联数据库 23
- 澳大利亚工业化学品名录(AICIS)
- 东盟化妆品指令
- 韩国安全保健公团 安全数据表
- 韩国食药处 化妆品法规信息 2 3 4
- 韩国有毒物质 GHS 信息(环境公团)
- 美国EPA 化学品数据库(DSSTox)
- 美国EPA CompTox 2
- 美国FDA 物质登记(GSRS)
- 美国FDA 物质识别码(UNII)
- 欧盟 CosIng 成分清单 2
- 欧盟化妆品法规
- 欧盟限用成分(附录III)
- 英国化妆品法规
- 中国已使用化妆品原料目录(IECIC)
- ChEBI
- IARC 致癌性分类
- IFRA 香料标准
- NIST 化学网络手册
- PubChem 2
- Tlooto 学术文献检索 2 3 4 5
- UniChem 化学物质统一 ID
- Wikidata
- Wikipedia · 英语 · 日语 · 中文