P-aminodiphenylamine is an aromatic amine that is the 4-amino derivative of diphenylamine.
- Korean limit
- 2.0%
Definition
P-aminodiphenylamine is an aromatic amine that is the 4-amino derivative of diphenylamine. It has a role as an allergen. It is an aromatic amine and a secondary amino compound. It is functionally related to a diphenylamine.
Source: PubChem
US FDA substance register · UNII 007X4XXS71 · registered name N-PHENYL-P-PHENYLENEDIAMINE · single chemical substance
Cosmetic roles
Safety & regulatory references
- Restricted
- South Korea · Taiwan
Source: MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · Taiwan FDA cosmetic regulations
China
- Maximum concentration : 3%
Source: MFDS (Korea) cosmetic regulatory information
Korea’s toxic-substance GHS classification: Warning · H410 (category 1) · H302 (category 4) · H317 (category 1) · +1 more
Restriction III/8 · SCCS opinion: Opinion on N-Phenyl-p-phenylenediamine
Source: EU CosIng ingredient list
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010
Reviewed by CIR: Final Report on the Safety Assessment of N-Phenyl-p-Phenylenediamine, N-Phenyl-p-Phenylenediamine Hydrochloride, and N-Phenyl-p-Phenylenediamine Sulfate
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 101-54-2
- EC No.EU chemical inventory number
- 202-951-9
- DTXSIDUS EPA chemical ID
- DTXSID7025895
- DTXCIDUS EPA compound ID
- DTXCID805895
- IUPAC
- N~1~-Phenylbenzene-1,4-diamine
- Molecular formula
- C12H12N2
- Molecular weight
- 184.242 g/mol
Measured properties
- pH
- 8.9 ()
- Melting/freezing point
- 65~78 ℃
- Initial boiling point and range
- 354 ℃(at 7,5mmHg)
- Flash point
- 193 ℃
- Upper/lower flammability or explosive limits
- 5.5 / 0.7 %
- Vapour pressure
- (&, lt, 1mmHg at 20C)
- Water solubility
- 0.5 g/㎖ (at 20C)
- Vapour density
- 6.4
- Relative density
- 1.09 ()
- n-Octanol/water partition coefficient (Kow)
- 1.82 (est.)
- Auto-ignition temperature
- (&, gt, 500 C)
- Molecular weight
- 184.24
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 5 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Antioxidant2
- Intermediate1
- Dye1
- Catalyst1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
8 skin studies and 4 eye studies are on record.
The studies disagree (the most common conclusion covers 33%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 12 studies
- Skin sensitisation - category 1
Skin Sensitization · Screening - Sh
Skin Sensitization · Authoritative - SkinSens1
Skin Sensitization · QSAR Predicted - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Category 1
Skin Sensitization · Screening - Not classified
Skin Irritation · Screening - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Moderate or Mild Irritation
skin irritation: in vivo · Screening · other guideline: FIFRA volume 43, no. 143 August 22, 1978, part 163.81-5; TSCA volume 44, no. 145, July 26, 1979, part 772. 112-25 (EPA); FIFRA US EPA November 1982, Section 81-5 primary dermal irritation study; TSCA US EPA august 1982, acute exposure, pimary dermal irrit according to - Category 2B
Eye Irritation · Screening - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Moderate or Mild Irritation
eye irritation: in vivo · Screening · other guideline: EPA November 1982, section 81-4, pimary eye irritation study; TSCA EPA August 1982, acute exposure, pimary eye irritation according to
Source: US EPA CompTox dashboard
Related literature
- In vitro metabolism of the emerging contaminant 6PPD-quinone in human and rat liver microsomes: Kinetics, pathways, and mechanism. · 2024
- A bibliometric analysis of global research hotspots and progress on emerging environmental pollutants 6PPD and 6PPD-quinone from 2004 to 2024. · 2024
- Skin sensitization potency and cross‐reactivity of p‐phenylenediamine and its derivatives evaluated by non‐radioactive murine local lymph node assay and guinea‐pig maximization test · 2009
- Severe allergic hair dye reactions in 8 children · 2006
- Allergenicity Evaluation of N-(1-Methylheptyl)-N'- Phenyl- p-Phenylenediamine and 2- (Thiocyanomethylthio) Benzothiazole by the Guinea Pig Maximization Test · 2001
Linked databases 25
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- EU SCCS safety opinions
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem
- Taiwan FDA cosmetic ingredients
- Taiwan FDA cosmetic regulations
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- US National Toxicology Program reports
- Wikidata
- Wikipedia · English