Naproxen is a methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6.
定義
米国FDA 物質登録 · UNII 57Y76R9ATQ · 登録名 NAPROXEN · 単一の化学物質
Naproxen is a methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, a xenobiotic, a gout suppressant, a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor, an environmental contaminant and a drug allergen. It is a monocarboxylic acid and a methoxynaphthalene. It is a conjugate acid of a naproxen(1-).
出典: PubChem
化粧品での役割
安全性・規制情報
韓国の有害物質GHS分類なし · 既存化学物質
Other restriction: ban substances that deplete the ozone layer
出典: EU CosIng 成分リスト
詳しい資料 — 表示名・識別番号・物性・試験記録・文献
別名・識別情報
- CAS No.化学物質登録番号
- 22204-53-1
- EC No.EU化学物質目録番号
- 244-838-7
- DTXSID米国EPA化学物質番号
- DTXSID4040686
- DTXCID米国EPA化合物番号
- DTXCID2020686
- IUPAC
- (2S)-2-(6-Methoxynaphthalen-2-yl)propanoic acid
- 分子式
- C14H14O3
- 分子量
- 230.263 g/mol
製品が実際に使っている用途
米国EPAにこの成分を届け出た製品2件の用途です。化粧品以外の製品も含まれるため、上の数行がこの成分の主な使い道といえます。
- Softener and conditioner1
- Pharmaceutical (EPA)1
出典: 米国EPA CompTox
関連文献
- Cutaneous reaction to naproxen. · 1996
- The impact of liposomes on transdermal permeation of naproxen--in vitro studies. · 2014
- Chemopreventive Efficacy of Naproxen and Nitric Oxide–naproxen in Rodent Models of Colon, Urinary Bladder, and Mammary Cancers · 2009
- Abstract A94: Preventive effects of naproxen and NO‐naproxen in carcinogen induced models of urinary bladder, colon, and mammary cancers · 2009
- Comparative chemopreventive efficacy of Naproxen and NO-Naproxen in rodent models of colon and bladder cancer. · 2008