Naproxen is a methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6.
定义
美国FDA 物质登记 · UNII 57Y76R9ATQ · 登记名称 NAPROXEN · 单一化学物质
Naproxen is a methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, a xenobiotic, a gout suppressant, a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor, an environmental contaminant and a drug allergen. It is a monocarboxylic acid and a methoxynaphthalene. It is a conjugate acid of a naproxen(1-).
来源: PubChem
化妆品中的作用
安全与法规参考
未列入韩国有毒物质 GHS 分类 · 现有化学物质
Other restriction: ban substances that deplete the ozone layer
来源: 欧盟 CosIng 成分清单
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
- CAS No.化学物质登记号
- 22204-53-1
- EC No.欧盟化学品目录编号
- 244-838-7
- DTXSID美国EPA化学品编号
- DTXSID4040686
- DTXCID美国EPA化合物编号
- DTXCID2020686
- IUPAC
- (2S)-2-(6-Methoxynaphthalen-2-yl)propanoic acid
- 分子式
- C14H14O3
- 分子量
- 230.263 g/mol
产品实际使用的用途
这是向美国 EPA 申报含该成分的 2 款产品的用途。其中包括化妆品以外的产品,排在前几行的即为该成分的主要用途。
- Softener and conditioner1
- Pharmaceutical (EPA)1
来源: 美国EPA CompTox
相关文献
- Cutaneous reaction to naproxen. · 1996
- The impact of liposomes on transdermal permeation of naproxen--in vitro studies. · 2014
- Chemopreventive Efficacy of Naproxen and Nitric Oxide–naproxen in Rodent Models of Colon, Urinary Bladder, and Mammary Cancers · 2009
- Abstract A94: Preventive effects of naproxen and NO‐naproxen in carcinogen induced models of urinary bladder, colon, and mammary cancers · 2009
- Comparative chemopreventive efficacy of Naproxen and NO-Naproxen in rodent models of colon and bladder cancer. · 2008