What is this ingredient?

미국 FDA 물질 등록 · UNII N7TD9J649B · 등록명 NARINGIN · 단일 화학물질

Ingredient Dictionary

NARINGIN

Naringin is a disaccharide derivative that is (S)-naringenin substituted by a 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.

How much products actually contain

No product states its amount yet.

Of the products containing it, 0 list it before the 1% line and 2 after it (usually 1% or less).

Products using this ingredient

2 of 2 confirmed · likeliest to carry enough first

Definition

US FDA substance register · UNII N7TD9J649B · registered name NARINGIN · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Naringin is a disaccharide derivative that is (S)-naringenin substituted by a 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent. It is a member of 4'-hydroxyflavanones, a (2S)-flavan-4-one, a neohesperidoside, a dihydroxyflavanone and a disaccharide derivative. It is functionally related to a (S)-naringenin.

Source: PubChem

Cosmetic roles

Protects skin from outside irritantsSKIN PROTECTING

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ナリンギン: 本品は、次の化学式で表される有機化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

NARINGININCI나린진Korean label name (MFDS standard)4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (S)-SynonymナリンギンJapanese labelling name

CAS No.chemical registry number: 10236-47-2
EC No.EU chemical inventory number: 233-566-4
DTXSIDUS EPA chemical ID: DTXSID6022478
DTXCIDUS EPA compound ID: DTXCID302478

IUPAC: (2S)-5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1-benzopyran-7-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
Molecular formula: C27H32O14
Molecular weight: 580.539 g/mol

Measured properties

Appearance: Solid
Boiling point: 922.00 to 926.00 °C. @ 760.00 mm Hg
Melting point: 83 °C
Solubility: 1 mg/mL at 40 °C

Values measured on the substance itself, not a specification for a commercial raw material.

Source: PubChem

What products actually use it for

What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Flavouring and nutrient1
Humectant1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

1 skin studies and 2 eye studies are on record.

Classed as low1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 3 studies

Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 442B (Skin Sensitization: Local Lymph Node Assay: BrdU-ELISA)
Ambiguous
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) according to EU method B.48 (Isolated chicken eye test method for identifying occular corrosives and severe irritants) according to
Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) according to