What is this ingredient?

미국 FDA 물질 등록 · UNII 3X476D83QV · 등록명 NEOHESPERIDIN DIHYDROCHALONE · 단일 화학물질

Is there safety information?

네오헤스페리딘다이하이드로칼콘은 자몽과 오렌지 껍질에서 추출한 천연 감미료로, 주로 화장품에서 피부 진정 및 항산화 효과를 제공합니다. 사용 시 큰 부작용은 거의 없으나, 민감하게 반응할 수 있는 사람도 있으므로 주의가 필요합니다.

Are there usage precautions?

피부 진정, 항산화 (추천 피부타입: 모든 피부 타입에 무난하나, 주로 향료 및 감각 개선 용도로 민감성 피부에도 사용 가능)

All ingredients

Ingredient Dictionary

NEOHESPERIDIN DIHYDROCHALCONE

Neohesperidin dihydrochalcone is a member of the dihydrochalcones that is 3,2',4',6'-tetrahydroxy-4-methoxydihydrochalcone attached to a neohesperidosyl residue at position 4' via glycosidic linkage.

Definition

US FDA substance register · UNII 3X476D83QV · registered name NEOHESPERIDIN DIHYDROCHALONE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Neohesperidin dihydrochalcone is a member of the dihydrochalcones that is 3,2',4',6'-tetrahydroxy-4-methoxydihydrochalcone attached to a neohesperidosyl residue at position 4' via glycosidic linkage. It is found in sweet orange. It has a role as a xenobiotic, a sweetening agent, a plant metabolite and an environmental contaminant. It is a neohesperidoside, a disaccharide derivative and a member of dihydrochalcones.

Source: PubChem

Cosmetic roles

Listed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCEAdds flavour (lip and oral products)FLAVOURINGGives the product a scentPERFUMING

Safety & regulatory references

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ネオヘスペリジンジヒドロカルコン: 本品は、次の化学式で表されるフラボノイドである。

Source: JCIA labelling names (Japan)

Names & identifiers

NEOHESPERIDIN DIHYDROCHALCONEINCI네오헤스페리딘다이하이드로칼콘Korean label name (MFDS standard)ネオヘスペリジンジヒドロカルコンJapanese labelling name

CAS No.chemical registry number: 20702-77-6
EC No.EU chemical inventory number: 243-978-6
DTXSIDUS EPA chemical ID: DTXSID3025706
DTXCIDUS EPA compound ID: DTXCID305706

IUPAC: 3,5-Dihydroxy-4-[3-(3-hydroxy-4-methoxyphenyl)propanoyl]phenyl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
Molecular formula: C28H36O15
Molecular weight: 612.581 g/mol

Measured properties

Appearance: Neohesperidin dihydrochalcone appears as off-white crystals or powder. Insoluble in water. (NTP, 1992) · Off-white, odourless, crystalline powder. Approximately between 1 000 and 1 800 times as sweet as sucrose
Melting point: 313 to 313 °F (NTP, 1992)
Solubility: Insoluble (<1 mg/ml) (NTP, 1992) · Freely soluble in hot water, very slightly soluble in cold water, practically insoluble in ether and benzene

Values measured on the substance itself, not a specification for a commercial raw material.

Source: PubChem

What products actually use it for

What the 9 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Flavouring and nutrient4
Fragrance3
Deodorizer2

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 1 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 3 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 442B (Skin Sensitization: Local Lymph Node Assay: BrdU-ELISA)
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to