Neohesperidin dihydrochalcone is a member of the dihydrochalcones that is 3,2',4',6'-tetrahydroxy-4-methoxydihydrochalcone attached to a neohesperidosyl residue at position 4' via glycosidic linkage.
定义
美国FDA 物质登记 · UNII 3X476D83QV · 登记名称 NEOHESPERIDIN DIHYDROCHALONE · 单一化学物质
Neohesperidin dihydrochalcone is a member of the dihydrochalcones that is 3,2',4',6'-tetrahydroxy-4-methoxydihydrochalcone attached to a neohesperidosyl residue at position 4' via glycosidic linkage. It is found in sweet orange. It has a role as a xenobiotic, a sweetening agent, a plant metabolite and an environmental contaminant. It is a neohesperidoside, a disaccharide derivative and a member of dihydrochalcones.
来源: PubChem
化妆品中的作用
安全与法规参考
Other restriction: ban substances that deplete the ozone layer
来源: 欧盟 CosIng 成分清单
详细资料——标示名称、识别编号、物性、试验记录、文献
官方标示名称和定义
日本化妆品工业联合会标示名称 ネオヘスペリジンジヒドロカルコン: 本品は、次の化学式で表されるフラボノイドである。
来源: 日本化妆品工业联合会标示名称
别名和识别信息
- CAS No.化学物质登记号
- 20702-77-6
- EC No.欧盟化学品目录编号
- 243-978-6
- DTXSID美国EPA化学品编号
- DTXSID3025706
- DTXCID美国EPA化合物编号
- DTXCID305706
- IUPAC
- 3,5-Dihydroxy-4-[3-(3-hydroxy-4-methoxyphenyl)propanoyl]phenyl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
- 分子式
- C28H36O15
- 分子量
- 612.581 g/mol
实测物性
- 性状
- Neohesperidin dihydrochalcone appears as off-white crystals or powder. Insoluble in water. (NTP, 1992) · Off-white, odourless, crystalline powder. Approximately between 1 000 and 1 800 times as sweet as sucrose
- 熔点
- 313 to 313 °F (NTP, 1992)
- 溶解性
- Insoluble (<1 mg/ml) (NTP, 1992) · Freely soluble in hot water, very slightly soluble in cold water, practically insoluble in ether and benzene
这是对物质本身测得的数值，并非原料商品的规格。
来源: PubChem
产品实际使用的用途
这是向美国 EPA 申报含该成分的 9 款产品的用途。其中包括化妆品以外的产品，排在前几行的即为该成分的主要用途。
- Flavouring and nutrient4
- Fragrance3
- Deodorizer2
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 2 项、眼部试验 1 项。
试验结论基本一致（100%）。 这是对原料本身的试验记录，与成品中所含浓度下的刺激性不同。
查看全部 3 项试验
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 442B (Skin Sensitization: Local Lymph Node Assay: BrdU-ELISA) - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
来源: 美国EPA CompTox
相关文献
- Novel biocatalytic strategies for the sustainable production of flavour compounds · 2025
- Modulation of the expression and activity of cathepsin S in reconstructed human skin by neohesperidin dihydrochalcone. · 2022
- COMPUTATIONAL ASSESSMENT OF THE PHARMACOKINETICS AND TOXICITY OF THE INTENSIVE SWEETENERS · 2021
- Cosmetic kit, useful e.g. to treat oxidative stress, comprises first anhydrous composition having vitamin C, and second composition having neohesperidin dihydrochalcone, silicone elastomer and concave particles · 2009