Neohesperidin is a flavanone glycoside that is hesperitin having an 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety attached to the 7-hydroxy group.
Definition
US FDA substance register · UNII OA5C88H3L0 · registered name NEOHESPERIDIN · single chemical substance
Neohesperidin is a flavanone glycoside that is hesperitin having an 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety attached to the 7-hydroxy group. It has a role as an antineoplastic agent and a plant metabolite. It is a member of 4'-methoxyflavanones, a neohesperidoside, a monomethoxyflavanone, a dihydroxyflavanone, a member of 3'-hydroxyflavanones, a disaccharide derivative and a flavanone glycoside. It is functionally related to a hesperetin.
Source: PubChem
Cosmetic roles
Safety & regulatory references
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 13241-33-3
- EC No.EU chemical inventory number
- 236-216-9
- DTXSIDUS EPA chemical ID
- DTXSID60927668
- DTXCIDUS EPA compound ID
- DTXCID101527365
- IUPAC
- (2S)-5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-1-benzopyran-7-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
- Molecular formula
- C28H34O15
- Molecular weight
- 610.565 g/mol
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 2 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 442B (Skin Sensitization: Local Lymph Node Assay: BrdU-ELISA) - Ambiguous
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) according to EU method B.48 (Isolated chicken eye test method for identifying occular corrosives and severe irritants) according to - Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) according to
Source: US EPA CompTox dashboard
Related literature
- Valorization of residual biomass from essential oil extraction of Ammodaucus leucotrichus: A step towards sustainable cosmetic and pharmaceutical applications · 2025
- Modulation of the expression and activity of cathepsin S in reconstructed human skin by neohesperidin dihydrochalcone. · 2022
- COMPUTATIONAL ASSESSMENT OF THE PHARMACOKINETICS AND TOXICITY OF THE INTENSIVE SWEETENERS · 2021
- Repurposing FDA-approved phytomedicines, natural products, antivirals and cell protectives against SARS-CoV-2 (COVID-19) RNA-dependent RNA polymerase · 2020
- Neohesperidin suppresses IgE‐mediated anaphylactic reactions and mast cell activation via Lyn‐PLC‐Ca2+ pathway · 2019