Ingredient Dictionary

NEOMENTHOL

(+)-neomenthol is a p-menthan-3-ol.

Definition

(+)-neomenthol is a p-menthan-3-ol.

Source: PubChem

US FDA substance register · UNII 89S3KO7RR9 · registered name Neomenthol, (±)- · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Gives the product a scentPERFUMING

More data — names, identifiers, properties, test records, literature

Names & identifiers

NEOMENTHOLINCICyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2R,5S)-rel-Synonym

CAS No.chemical registry number: 3623-51-6
EC No.EU chemical inventory number: 222-824-1
DTXSIDUS EPA chemical ID: DTXSID20883998
DTXCIDUS EPA compound ID: DTXCID001325320

IUPAC: (1S,2S,5R)-5-Methyl-2-(propan-2-yl)cyclohexan-1-ol
Molecular formula: C10H20O
Molecular weight: 156.269 g/mol

Measured properties

Appearance: D,l-menthol is a white crystalline solid with a peppermint odor and taste. (NTP, 1992) · Other Solid, Liquid
Boiling point: 421 °F at 760 mmHg (NTP, 1992) · 95.00 °C. @ 12.00 mm Hg
Melting point: 100 °F (NTP, 1992) · -22 °C
Solubility: less than 1 mg/mL at 70 °F (NTP, 1992) · very soluble in alcohol and volatile oils, slightly soluble in water
Density: 0.904 at 59 °F (NTP, 1992) - Less dense than water, will float · 0.901 (20 °C), 0.891 (30 °C)

Values measured on the substance itself, not a specification for a commercial raw material.

Source: PubChem

What products actually use it for

What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Fragrance3

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

3 skin studies and 4 eye studies are on record.

Classed as highly irritating2Classed as low2

The studies disagree (the most common conclusion covers 50%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 7 studies

Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) other: Kimber, I, Hilton, J., Weisenberger, C., The murine local lymph node assay for identification of contact allergens: A preliminary evaluation of in situ measurement of lymphocyte proliferation. Contact Dermatitis, 21, 215- 220, 19 according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Severe Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) 1981's version according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Ambiguous
eye irritation: in vitro / ex vivo · Screening · OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants) [before 26 July 2013] according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) 1989 according to
Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to