(+)-neomenthol is a p-menthan-3-ol.
定義
(+)-neomenthol is a p-menthan-3-ol.
出典: PubChem
米国FDA 物質登録 · UNII 89S3KO7RR9 · 登録名 Neomenthol, (±)- · 単一の化学物質
化粧品での役割
製品に香りをつけるPERFUMING
詳しい資料 — 表示名・識別番号・物性・試験記録・文献
別名・識別情報
NEOMENTHOLINCICyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2R,5S)-rel-別名
- CAS No.化学物質登録番号
- 3623-51-6
- EC No.EU化学物質目録番号
- 222-824-1
- DTXSID米国EPA化学物質番号
- DTXSID20883998
- DTXCID米国EPA化合物番号
- DTXCID001325320
- IUPAC
- (1S,2S,5R)-5-Methyl-2-(propan-2-yl)cyclohexan-1-ol
- 分子式
- C10H20O
- 分子量
- 156.269 g/mol
測定された物性
- 性状
- D,l-menthol is a white crystalline solid with a peppermint odor and taste. (NTP, 1992) · Other Solid, Liquid
- 沸点
- 421 °F at 760 mmHg (NTP, 1992) · 95.00 °C. @ 12.00 mm Hg
- 融点
- 100 °F (NTP, 1992) · -22 °C
- 溶解性
- less than 1 mg/mL at 70 °F (NTP, 1992) · very soluble in alcohol and volatile oils, slightly soluble in water
- 密度
- 0.904 at 59 °F (NTP, 1992) - Less dense than water, will float · 0.901 (20 °C), 0.891 (30 °C)
物質そのものを測定した値で、原料商品の規格ではありません。
出典: PubChem
製品が実際に使っている用途
刺激・感作試験の記録
皮膚試験3件・眼試験4件の記録があります。
刺激が強いと分類2件低いと分類2件
試験ごとに結論が分かれています（最も多い結論の割合 50%）。この成分が刺激性だとは言い切れないということです。 原料そのものを試験した記録で、完成品に含まれる濃度での刺激性とは異なります。
試験7件をすべて見る
- Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) other: Kimber, I, Hilton, J., Weisenberger, C., The murine local lymph node assay for identification of contact allergens: A preliminary evaluation of in situ measurement of lymphocyte proliferation. Contact Dermatitis, 21, 215- 220, 19 according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay) - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Severe Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) 1981's version according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Ambiguous
eye irritation: in vitro / ex vivo · Screening · OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants) [before 26 July 2013] according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) 1989 according to - Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
出典: 米国EPA CompTox
関連文献
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- Phytomolecules from Cynodon dactylon and Delonix regia has the Potential for Skin Cancer · 2024
- Peppermint essential oil: its phytochemistry, biological activity, pharmacological effect and application. · 2022
- Neomenthol prevents the proliferation of skin cancer cells by restraining tubulin polymerization and hyaluronidase activity · 2021
- Cytotoxic Activity of Cunila angustifolia Essential Oil · 2020