Neopentyl glycol is a propane-1,3-diol carrying two methyl groups at position 2.
Definition
Neopentyl glycol is a propane-1,3-diol carrying two methyl groups at position 2.
Source: PubChem
US FDA substance register · UNII QI80HXD6S5 · registered name NEOPENTYL GLYCOL · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ネオペンチルグリコール: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 126-30-7
- EC No.EU chemical inventory number
- 204-781-0
- DTXSIDUS EPA chemical ID
- DTXSID8027036
- DTXCIDUS EPA compound ID
- DTXCID007036
- IUPAC
- 2,2-Dimethylpropane-1,3-diol
- Molecular formula
- C5H12O2
- Molecular weight
- 104.149 g/mol
Measured properties
- Appearance
- liquid
- Melting/freezing point
- 130 ℃
- Initial boiling point and range
- 210 ℃
- Flash point
- 107 ℃
- Upper/lower flammability or explosive limits
- -11.4 / -1.1 %
- Vapour pressure
- 0.22506 ㎜Hg (at 20C)
- Water solubility
- (10.3g/l at 20C)
- Vapour density
- 3.6
- Relative density
- 1.1
- n-Octanol/water partition coefficient (Kow)
- 0.16
- Auto-ignition temperature
- 388 ℃
- Viscosity
- (4.2 mPas (150 C))
- Molecular weight
- 104.15
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 27 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Solvent5
- Processing aids not otherwise specified4
- Plasticizer3
- Monomers3
- Intermediate3
- Surfactant (surface active agent)2
- Dye2
- Filler2
3 other uses
- Lubricating agent1
- Chemical reaction regulator1
- Elasticizer1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- LC-MS Identification of Phthalates of Neopentyl/Propylene Glycol and Quaternary Ammonium Cations in Nail Conditioners · 2026
- Green Production of a High-Value Branched-Chain Diester: Optimization Based on Operating Conditions and Economic and Sustainability Criteria · 2023
- Efficient Expression, Purification, and Visualization by Cryo-EM of Unliganded Near Full-Length HER3 · 2022
- Safety Assessment of Trimellitic Anhydride Copolymers as Used in Cosmetics · 2020
- Molecular Aspects of Film Formation of Partially Cross-Linked Water-Borne Secondary Dispersions that Show Skin Formation upon Drying · 2019
Linked databases 18
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Chinese