Neosaxitoxin is a pyrrolopurine that is saxitoxin carrying a hydroxy substituent on the nitrogen atom at position 5.
Definición
Registro de sustancias de la FDA (EE. UU.) · UNII 6YRL8BWD9H · nombre registrado NEOSAXITOXIN · sustancia química única
Fuente: Identificador único de ingredientes de la FDA (UNII)
Neosaxitoxin is a pyrrolopurine that is saxitoxin carrying a hydroxy substituent on the nitrogen atom at position 5. It is a sodium channel blocker that is undergoing clinical trials as a prolonged-duration local anesthetic. It has a role as a toxin, a local anaesthetic, a voltage-gated sodium channel blocker, a neurotoxin, an anti-inflammatory agent, a marine metabolite and a cyanotoxin. It is a pyrrolopurine, a paralytic shellfish toxin, an alkaloid, a carbamate ester, a member of guanidines, a member of hydroxylamines and a ketone hydrate. It is functionally related to a saxitoxin.
Fuente: PubChem
Neosaxitoxin is a neurotoxin isolated from algae cyanobacteria cells. It conforms to the formula
Funciones cosméticas
Más datos: nombres, identificadores, propiedades, ensayos y literatura
Nombres e identificadores
- CAS No.número de registro químico
- 64296-20-4
- EC No.número de inventario químico de la UE
- 809-831-0
- DTXSIDidentificador químico de la EPA (EE. UU.)
- DTXSID70880098
- DTXCIDidentificador de compuesto de la EPA (EE. UU.)
- DTXCID401529215
- IUPAC
- [(3aS,4R,10aS)-2-Amino-5,10,10-trihydroxy-6-imino-3a,4,5,6,9,10-hexahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate
- Fórmula molecular
- C10H17N7O5
- Peso molecular
- 315.29 g/mol
Para qué lo usan los productos
Usos de los 5 productos declarados ante la EPA de EE. UU. con este ingrediente. Incluye productos que no son cosméticos, así que las primeras filas son sus usos principales.
- Astringent (EPA)1
- Antioxidant1
- Antiperspirant (EPA)1
- Dye1
- Humectant1
Fuente: Panel CompTox de la EPA
Literatura relacionada
- Site-1 Sodium Channel Blockers as Local Anesthetics: Will Neosaxitoxin Supplant the Need for Continuous Nerve Blocks? · 2015
- Neosaxitoxin, a Long-Lasting Local Anesthetic and its Potential Clinical Applications in Horses · 2023
- Faculty Opinions recommendation of A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia. · 2017
- A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia · 2015
- Neosaxitoxin as a Local Anesthetic: Preliminary Observations from a First Human Trial · 2007
Bases de datos vinculadas 12
- Base de datos química DSSTox de la EPA
- Búsqueda bibliográfica Tlooto 2 3 4 5
- ChEBI
- ChEMBL
- Identificador único de ingredientes de la FDA (UNII)
- Identificadores cruzados UniChem
- Lista de ingredientes CosIng (UE) 2
- Panel CompTox de la EPA 2
- PubChem
- Registro de sustancias de la FDA (GSRS)
- Wikidata
- Wikipedia · inglés