Neosaxitoxin is a pyrrolopurine that is saxitoxin carrying a hydroxy substituent on the nitrogen atom at position 5.
定义
美国FDA 物质登记 · UNII 6YRL8BWD9H · 登记名称 NEOSAXITOXIN · 单一化学物质
Neosaxitoxin is a pyrrolopurine that is saxitoxin carrying a hydroxy substituent on the nitrogen atom at position 5. It is a sodium channel blocker that is undergoing clinical trials as a prolonged-duration local anesthetic. It has a role as a toxin, a local anaesthetic, a voltage-gated sodium channel blocker, a neurotoxin, an anti-inflammatory agent, a marine metabolite and a cyanotoxin. It is a pyrrolopurine, a paralytic shellfish toxin, an alkaloid, a carbamate ester, a member of guanidines, a member of hydroxylamines and a ketone hydrate. It is functionally related to a saxitoxin.
来源: PubChem
Neosaxitoxin is a neurotoxin isolated from algae cyanobacteria cells. It conforms to the formula
化妆品中的作用
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
- CAS No.化学物质登记号
- 64296-20-4
- EC No.欧盟化学品目录编号
- 809-831-0
- DTXSID美国EPA化学品编号
- DTXSID70880098
- DTXCID美国EPA化合物编号
- DTXCID401529215
- IUPAC
- [(3aS,4R,10aS)-2-Amino-5,10,10-trihydroxy-6-imino-3a,4,5,6,9,10-hexahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate
- 分子式
- C10H17N7O5
- 分子量
- 315.29 g/mol
产品实际使用的用途
这是向美国 EPA 申报含该成分的 5 款产品的用途。其中包括化妆品以外的产品，排在前几行的即为该成分的主要用途。
- Astringent (EPA)1
- Antioxidant1
- Antiperspirant (EPA)1
- Dye1
- Humectant1
来源: 美国EPA CompTox
相关文献
- Site-1 Sodium Channel Blockers as Local Anesthetics: Will Neosaxitoxin Supplant the Need for Continuous Nerve Blocks? · 2015
- Neosaxitoxin, a Long-Lasting Local Anesthetic and its Potential Clinical Applications in Horses · 2023
- Faculty Opinions recommendation of A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia. · 2017
- A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia · 2015
- Neosaxitoxin as a Local Anesthetic: Preliminary Observations from a First Human Trial · 2007