Nerolidol is a farnesane sesquiterpenoid that is dodeca-1,6,10-triene which carries methyl groups at positions 3, 7 and 11 and a hydroxy group at position 3.
Definition
Nerolidol is a farnesane sesquiterpenoid that is dodeca-1,6,10-triene which carries methyl groups at positions 3, 7 and 11 and a hydroxy group at position 3. It is a natural product that is present in various flowers and plants with a floral odor. Chemically, it exists in two geometric isomers, trans and cis forms. It is widely used in cosmetics (e.g. shampoos and perfumes), in non-cosmetic products (e.g. detergents and cleansers) and also as a food flavoring agent. It has a role as an antioxidant, a herbicide, an insect attractant, a pheromone, a volatile oil component, a flavouring agent, an antihypertensive agent, an antifungal agent, a neuroprotective agent, a cosmetic and an anti-inflammatory agent. It is a volatile organic compound, a tertiary allylic alcohol and a farnesane sesquiterpenoid.
Source: PubChem
US FDA substance register · UNII QR6IP857S6 · registered name NEROLIDOL · mixture
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 7212-44-4
- EC No.EU chemical inventory number
- 230-597-5
- DTXSIDUS EPA chemical ID
- DTXSID3022247
- DTXCIDUS EPA compound ID
- DTXCID602247
- IUPAC
- 3,7,11-Trimethyldodeca-1,6,10-trien-3-ol
- Molecular formula
- C15H26O
- Molecular weight
- 222.372 g/mol
Measured properties
- Appearance
- Liquid · Colourless or very pale straw-coloured oily liquid, Faint woody-floral, slightly rose apple aroma
- Boiling point
- 275-277 °C
- Solubility
- Soluble in most fixed oils and propylene glycol, slightly soluble in water, insoluble in glycerol · Soluble (in ethanol)
- Density
- 0.872-0.879
- Melting/freezing point
- -90 ℃
- Initial boiling point and range
- 276 ℃
- Flash point
- 128 ℃(c.c)
- Vapour pressure
- 0.0024 hPa (@ 20 °C)
- Water solubility
- 14.1 ㎎/ℓ (@ 20 °C)
- Relative density
- 0.88 (@ 20 °C)
- n-Octanol/water partition coefficient (Kow)
- 4.5 (@ 24 °C)
- Auto-ignition temperature
- 237 ℃ (@ 1001 ~ 1016 mBar)
- Viscosity
- 15.8 cSt (@ 20 °C, 6.41 mm²/s @ 40 °C, 13.8 mPa s @ 20 °C, 5.5 mPa s @ 40 °C)
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 37 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance35
- Flavouring and nutrient2
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 1 studies
- Low to Moderate Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Source: US EPA CompTox dashboard
Linked databases 13
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- PubChem 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese