Are there usage precautions?

미백(melanosome transfer억제)/ 주름개선 보호막 피부 보수 효과 Niacinamide supports skin health by boosting the synthesis of cellular energy molecules (NAD+), contributing to DNA repair and cellular metabolism that maintain skin homeostasis. Its antioxidant capabilities reduce oxidative stress by neutralizing reactive oxygen species (ROS), thereby preventing premature aging and glycation-associated yellowing of the skin. Niacinamide reduces inflammation by inhibiting inflammatory cytokines and stabilizing mast cells, which helps prevent fibroblast aging and supports collagen and elastin production, enhancing skin firmness and elasticity. It improves the skin barrier by stimulating ceramide production, which enhances hydration and protection against irritants. Niacinamide also inhibits melanin transfer, reducing hyperpigmentation, and regulates sebum production, making it effective against acne and redness. (추천 피부타입: 모든피부타입)

All ingredients

Ingredient Dictionary

NIACINAMIDE

Nicotinamide is a pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.

Clinical evidence

Dark spots B
Oiliness B-
Skin barrier B-
Blemishes B-
Pores C
Lines C

Amount studies used: 2–5%
When: morning and evening
Irritation: low

Grades were set by reading this ingredient’s studies. They describe the ingredient, not every product that contains it.

NIACINAMIDE Molecular structure — Molecular structure

How much products actually contain

288 products state the amountmedian 2%86% at or above the amount studies used (2–5%)

under 0.01% 20
0.01–0.1% 6
0.1–1% 10
1% or more 252

Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.

1,173 products are filed with Korea's MFDS as brightening functional cosmetics, which fixes it at the notified amount (2–5%) or more.

Of the products containing it, 4,327 list it before the 1% line and 592 after it (usually 1% or less).

Where no amount is stated, a product listing it early reaches the study amount about 93% of the time, one listing it late about 25%.

Clinical evidence grade by skin concern

B: one or two randomised trials
C: uncontrolled or multi-ingredient studies

5 references

Products using this ingredient

12 of 4,850 confirmed · likeliest to carry enough first · See all 4,850

Definition

Nicotinamide is a pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group. It has a role as a geroprotector, an antioxidant, a cofactor, a metabolite, an EC 3.5.1.98 (histone deacetylase) inhibitor, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a neuroprotective agent, an anti-inflammatory agent, a Sir2 inhibitor, a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a human urinary metabolite. It is a vitamin B3, a pyridinecarboxamide and a pyridine alkaloid. It is functionally related to a nicotinic acid.

Source: PubChem

US FDA substance register · UNII 25X51I8RD4 · registered name NIACINAMIDE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Reduces surface roughnessSMOOTHING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Reviewed by CIR: Final Report on the Safety Assessment of Niacinamide and Niacin

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ナイアシンアミド: 本品は、次の化学式で表される複素環式芳香族アミドである。

Source: JCIA labelling names (Japan)

Names & identifiers

NIACINAMIDEINCI나이아신아마이드Korean label name (MFDS standard)3-PyridinecarboxamideSynonymナイアシンアミドJapanese labelling name

CAS No.chemical registry number: 98-92-0
EC No.EU chemical inventory number: 202-713-4
DTXSIDUS EPA chemical ID: DTXSID2020929
DTXCIDUS EPA compound ID: DTXCID00929

IUPAC: Pyridine-3-carboxamide
Molecular formula: C6H6N2O
Molecular weight: 122.127 g/mol

Measured properties

Appearance: Nicotinamide is a white powder. (NTP, 1992) · Dry Powder
Odour: Odorless · odourless
Boiling point: 302 to 320 °F at 760 mmHg (NTP, 1992) · 157 °C at 5.00E-04 mm Hg
Melting point: 264 to 268 °F (NTP, 1992) · 130 °C
Solubility: greater than or equal to 100 mg/mL at 70 °F (NTP, 1992) · 500000 mg/L (at 25 °C)
Density: 1.4 (NTP, 1992) - Denser than water, will sink · 1.400 g/cu cm at 25 °C
Stability: Stable under recommended storage conditions. · ... Niacinamide is incompatible with alkalis and strong acids.
pH: 10% "wt in vol" solution in water is neutral to litmus
Dissociation constant: 3.35 (at 20 °C) · pKa = 3.35 (conjugate acid)
Colour: white
Melting/freezing point: 127~131 ℃
Initial boiling point and range: 157 ℃(5X10-4 mmHg)
Flash point: 182 ℃
Flammability (solid, gas): combustible
Vapour pressure: 0.00042 ㎜Hg (25℃(est))
Water solubility: 500000 ㎎/ℓ (@ 20 ℃)
Vapour density: 4.2
Relative density: 1.400 (@ 25 ℃)
n-Octanol/water partition coefficient (Kow): -0.38
Auto-ignition temperature: 480 ℃
Molecular weight: 122.12

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 28 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Softener and conditioner20
Flavouring and nutrient3
Processing aids not otherwise specified2
Humectant2
Intermediate1

Source: US EPA CompTox dashboard