NAD zwitterion is a NAD.
How much products actually contain
8 products state the amountmedian 0.005%
- under 0.01% 5
- 0.01–0.1% 2
- 0.1–1% 0
- 1% or more 1
Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.
Of the products containing it, 15 list it before the 1% line and 44 after it (usually 1% or less).
Products using this ingredient
12 of 59 confirmed · likeliest to carry enough first · See all 59
Cos De BAHAND Serum10% stated
S.NATUREAqua Collagen Peptide NAD+ Ampoule0.05% stated
S.NATUREAqua Collagen Peptide NAD+ Cream0.05% stated
Haruharu WonderHaruharu Wonder Probiotics Barrier 2% NAD + Serum Mist
ChardeLiftcera Gel Mask
VTSkin Barrier Synergy Cream EX Plus
ChardeWrinkle Tox Glabella Patch 4mg x 9 Patches
Tender GardenSkin Renewal Sun Serum SPF 50+ PA++++
PIXELPURESlow Aging Cream Wrapping Mask Sheet
LAVIENLAVIEN D.N.A Cell Revital Firming Cream
NACIFICRice Peptide Collagen Lip Treatment
KAHIKAHI Eye Balm CV (Original)
Definition
NAD zwitterion is a NAD. It has a role as a geroprotector. It is functionally related to a deamido-NAD zwitterion. It is a conjugate base of a NAD(+).
Source: PubChem
US FDA substance register · UNII 0U46U6E8UK · registered name NADIDE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ニコチンアミドアデニンジヌクレオチド: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 53-84-9
- EC No.EU chemical inventory number
- 200-184-4
- DTXSIDUS EPA chemical ID
- DTXSID2045236
- DTXCIDUS EPA compound ID
- DTXCID0025236
- Molecular formula
- C21H27N7O14P2
- Molecular weight
- 663.43 g/mol
Measured properties
- Appearance
- Highly hygroscopic white solid, [Merck Index] White powder, [Sigma-Aldrich MSDS] · Solid
- Melting point
- 140.0 - 142.0 °C
- Solubility
- 752.5 mg/mL
- pH
- 2 (1% soln)
- Melting/freezing point
- 140~142 ℃
- n-Octanol/water partition coefficient (Kow)
- -3.68
- Molecular weight
- 663.43
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Source: US EPA CompTox dashboard
Related literature
- Nicotinamide adenine dinucleotide fluorescence monitoring as a potential tool for the microvascular and mitochondrial function assessment in heart failure · 2025
- Metabolic profiles of cutaneous lupus have abnormalities in the nicotinamide adenine dinucleotide pathway · 2025
- A Narrative Review of Nicotinamide Adenine Dinucleotide (NAD)+ Intermediates Nicotinamide Riboside and Nicotinamide Mononucleotide for Keratinocyte Carcinoma Risk Reduction. · 2022
- Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors · 2021
- Decrease in nicotinamide adenine dinucleotide dehydrogenase is related to skin pigmentation · 2012
Linked databases 18
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI 2
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata 2