Nifedipine can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements.
Definition
US FDA substance register · UNII I9ZF7L6G2L · registered name Nifedipine · single chemical substance
Nifedipine can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements.
Source: PubChem
Nifedipine is the organic compound that conforms to the formula:
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 21829-25-4
- DTXSIDUS EPA chemical ID
- DTXSID2025715
- DTXCIDUS EPA compound ID
- DTXCID205715
- IUPAC
- Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- Molecular formula
- C17H18N2O6
- Molecular weight
- 346.339 g/mol
Measured properties
- Appearance
- solid
- Melting/freezing point
- 172~174 ℃
- Vapour pressure
- 0.0000000234 ㎜Hg (at 25℃ (est.))
- Water solubility
- 56.3 ㎎/ℓ (at 25℃ (est.))
- n-Octanol/water partition coefficient (Kow)
- 2.20
- Molecular weight
- 346.37
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Antioxidant1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- Category 6.5B (Category 1)
Skin Sensitization · Read Across - SkinSens1
Skin Sensitization · QSAR Predicted
Source: US EPA CompTox dashboard
Related literature
- Prevention of Hypertension at Intubation: A Controlled Study of Sublingual Nifedipine · 2020
- Comparison of Topical Nifedipine With Oral Nifedipine for Treatment of Anal Fissure: A Randomized Controlled Trial · 2014
- Treatment of periocular wrinkles with topical nifedipine · 2010
- Pemphigus foliaceus induced by nifedipine. · 1993
- RESEARCH ON NIFEDIPINE PATCH · 1991
Linked databases 15
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese