Nobiletin is a methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3' and 4' respectively.
Definition
Nobiletin is a methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3' and 4' respectively. It has a role as an antineoplastic agent and a plant metabolite. It is functionally related to a flavone.
Source: PubChem
US FDA substance register · UNII D65ILJ7WLY · registered name NOBILETIN · single chemical substance
Nobiletin is the organic compound that conforms to the formula.
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 478-01-3
- DTXSIDUS EPA chemical ID
- DTXSID30197275
- DTXCIDUS EPA compound ID
- DTXCID40119766
- IUPAC
- 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one
- Molecular formula
- C21H22O8
- Molecular weight
- 402.399 g/mol
Measured properties
- Appearance
- Solid · gas
- Melting point
- 134 °C
- Melting/freezing point
- -133.89 ℃(est.)
- Molecular weight
- 44.10 (est.)
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Preservative1
- Biocide1
- Antioxidant1
Source: US EPA CompTox dashboard
Related literature
- Nobiletin Induces Ferroptosis in Human Skin Melanoma Cells Through the GSK3β-Mediated Keap1/Nrf2/HO-1 Signalling Pathway · 2022
- Nobiletin mitigates benign prostatic hyperplasia by suppressing prostate cell proliferation through regulation of cell cycle progression, signaling pathways, transcription factor activity, and the androgen-signaling axis · 2025
- Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells · 2021
- Antioxidant Nobiletin Enhances Oocyte Maturation and Subsequent Embryo Development and Quality · 2020
- 175 Nobiletin enhances the quality of in vitro-matured bovine oocytes and blastocysts by altering the transcription of key developmental genes · 2019
Linked databases 15
- ChEBI
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese