Nordihydroguaiaretic acid is a tetrol that is butane which is substituted at positions 2 and 3 by 3,4-dihydroxybenzyl groups.
How much products actually contain
No product states its amount yet.
Of the products containing it, 1 list it before the 1% line and 2 after it (usually 1% or less).
Products using this ingredient
3 of 3 confirmed · likeliest to carry enough first
Definition
Nordihydroguaiaretic acid is a tetrol that is butane which is substituted at positions 2 and 3 by 3,4-dihydroxybenzyl groups. Masoprocol, the meso-form found in the leaves of the creosote bush (Larrea divaricata), is a potent lipoxygenase inhibitor. It has a role as a ferroptosis inhibitor, a geroprotector, an antioxidant and a plant metabolite. It is a lignan, a member of catechols and a tetrol.
Source: PubChem
US FDA substance register · UNII 7BO8G1BYQU · registered name MASOPROCOL · single chemical substance
Cosmetic roles
Safety & regulatory references
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ノルジヒドログアイアレチン酸: 本品は、次の化学式で表されるリグナン誘導体である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 500-38-9
- EC No.EU chemical inventory number
- 207-903-0
- DTXSIDUS EPA chemical ID
- DTXSID5022437
- DTXCIDUS EPA compound ID
- DTXCID702437
- IUPAC
- 4,4'-(2,3-Dimethylbutane-1,4-diyl)di(benzene-1,2-diol)
- Molecular formula
- C18H22O4
- Molecular weight
- 302.37 g/mol
Measured properties
- Appearance
- Solid, [Merck Index] White odorless powder, [Alfa Aesar MSDS] · solid
- Colour
- white
- Melting/freezing point
- 185.5 ℃
- Initial boiling point and range
- 4.640 ℃
- n-Octanol/water partition coefficient (Kow)
- 4.64
- Molecular weight
- 302.40
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Antioxidant3
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- SkinSens1
Skin Sensitization · QSAR Predicted - SkinIrr2
Skin Irritation · QSAR Predicted
Source: US EPA CompTox dashboard
Related literature
- Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells · 2002
- Nordihydroguaiaretic acid enhances the activities of aminoglycosides against methicillin- sensitive and resistant Staphylococcus aureus in vitro and in vivo · 2015
- Impact on Inflammation and Recovery of Skin Barrier by Nordihydroguaiaretic Acid as a Protease-Activated Receptor 2 Antagonist · 2012
- Nordihydroguaiaretic Acid from Creosote Bush (Larrea tridentata) Mitigates 12-O-Tetradecanoylphorbol-13-Acetate-Induced Inflammatory and Oxidative Stress Responses of Tumor Promotion Cascade in Mouse Skin · 2011
- Nordy (dl-nordihydroguaiaretic acid) Inhibits the Growth of Malignant Human Glioma by Attenuating Formylpeptide Receptor-mediated Signaling · 2006
Linked databases 18
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI 2
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Chinese