2-aminophenol is the aminophenol which has the single amino substituent located ortho to the phenolic -OH group.
Definition
2-aminophenol is the aminophenol which has the single amino substituent located ortho to the phenolic -OH group. It has a role as a bacterial metabolite.
Source: PubChem
US FDA substance register · UNII 23RH73DZ65 · registered name 2-Aminophenol · single chemical substance
Cosmetic roles
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · China · European Union · South Korea
Source: ASEAN Cosmetic Directive · MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Restriction II/1372 · Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2005/2006
Reviewed by CIR: Final Report on the Safety Assessment of p-Aminophenol, m-Aminophenol, and o-Aminophenol
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 95-55-6
- EC No.EU chemical inventory number
- 202-431-1
- DTXSIDUS EPA chemical ID
- DTXSID8024498
- DTXCIDUS EPA compound ID
- DTXCID104498
- IUPAC
- 2-Aminophenol
- Molecular formula
- C6H7NO
- Molecular weight
- 109.128 g/mol
Measured properties
- pH
- 7
- Melting/freezing point
- 172 ℃
- Flash point
- &, gt, 175 ℃ (c.c.)
- Water solubility
- 1.7 g/100㎖ (20℃)
- Vapour density
- 3.77
- Relative density
- 1.328
- n-Octanol/water partition coefficient (Kow)
- 0.62
- Auto-ignition temperature
- 190 ℃
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Dye3
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: US Code of Fed Reg 16, Sec 1500.41 according to - Not classified
Skin Irritation · Screening - Category 1
Skin Sensitization · Screening - Not classified
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- Malignant syphilis with ocular involvement in an immunocompetent patient · 2014
- [The expanding role of occupational and non-occupational allergy to paraphenylenediamine]. · 2007
- Synthesis and Topical Antiinflammatory and Antiallergic Activities of Antioxidant o‐Aminophenol Derivatives. · 1994
- Synthesis and topical antiinflammatory and antiallergic activities of antioxidant o-aminophenol derivatives. · 1994
- 2 Final Report on the Safety Assessment of p-Aminophenol, m-Aminophenol, and o-Aminophenol · 1988
Linked databases 23
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- EU SCCS safety opinions
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese