Octopamine is a member of the class of phenylethanolamines that is phenol which is substituted at the para- position by a 2-amino-1-hydroxyethyl group.
Definition
Octopamine is a member of the class of phenylethanolamines that is phenol which is substituted at the para- position by a 2-amino-1-hydroxyethyl group. A biogenic phenylethanolamine which has been found to act as a neurotransmitter, neurohormone or neuromodulator in invertebrates. It has a role as a neurotransmitter. It is a member of phenylethanolamines and a member of tyramines. It is a conjugate base of an octopaminium.
Source: PubChem
US FDA substance register · UNII 14O50WS8JD · registered name OCTOPAMINE · single chemical substance
Cosmetic roles
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea
Source: MFDS (Korea) cosmetic regulatory information
Restriction II/21
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 104-14-3
- EC No.EU chemical inventory number
- 203-179-5
- DTXSIDUS EPA chemical ID
- DTXSID7043873
- DTXCIDUS EPA compound ID
- DTXCID5023873
- IUPAC
- 4-(2-Amino-1-hydroxyethyl)phenol
- Molecular formula
- C8H11NO2
- Molecular weight
- 153.181 g/mol
What products actually use it for
What the 4 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Pharmaceutical (EPA)3
- Softener and conditioner1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 1 studies
- SkinSens1
Skin Sensitization · QSAR Predicted
Source: US EPA CompTox dashboard
Related literature
- Augmented analgesic effect of tyramine or octopamine in combination with lidocaine is mediated with α-adrenergic receptors. · 2025
- Characterization of an octopamine receptor, and its involvement in the immune response of cuttlefish Sepiella japonica. · 2025
- Pharmacological characterization of a β-adrenergic-like octopamine receptor in Plutella xylostella. · 2018
- Effects of physical and social experiences and octopamine receptor agonist on fighting behavior of male crickets Velarifictorus aspersus (Orthoptera: Gryllidae) · 2018
- Selective regulation of sensitivity to odours of different behavioural significance in the American cockroach, Periplaneta americana · 2008
Linked databases 13
- ChEBI 2
- ChEMBL
- EU CosIng ingredient list 2
- MFDS (Korea) cosmetic regulatory information 2 3
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese