What is this ingredient?

미국 FDA 물질 등록 · UNII 4LFS24GD0V · 등록명 OCTHILINONE · 단일 화학물질

Ingredient Dictionary

OCTYLISOTHIAZOLINONE

Octhilinone is a member of the class of 1,2-thiazole that is 1,2-thiazol-3-one substituted on the nitrogen (position 2) by an octyl group.

Definition

US FDA substance register · UNII 4LFS24GD0V · registered name OCTHILINONE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Octhilinone is a member of the class of 1,2-thiazole that is 1,2-thiazol-3-one substituted on the nitrogen (position 2) by an octyl group. A fungicide and antibacterial agent, it is used for treatment of canker and other fungal and bacterial diseases in fruit trees. It is no longer approved for use within the European Union. It has a role as an antibacterial agent, a xenobiotic, an environmental contaminant and an antifungal agrochemical.

Source: PubChem

Cosmetic roles

Inhibits microbial growthANTIMICROBIAL

Safety & regulatory references

Korea’s toxic-substance GHS classification: Danger · H302 (category 4) · H330 (category 2) · H314 (category 1) · +5 more

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Names & identifiers

OCTYLISOTHIAZOLINONEINCI3(2H)-Isothiazolone, 2-octyl-Synonym

CAS No.chemical registry number: 26530-20-1
EC No.EU chemical inventory number: 247-761-7
DTXSIDUS EPA chemical ID: DTXSID1025805
DTXCIDUS EPA compound ID: DTXCID105805

IUPAC: 2-Octyl-1,2-thiazol-3(2H)-one
Molecular formula: C11H19NOS
Molecular weight: 213.34 g/mol

Measured properties

Appearance: 2-octyl-3-isothiazolone is a clear dark amber liquid. Used as a fungicide. · Clear dark amber liquid, [CAMEO]
Odour: Very weak, sharp smell
Boiling point: 248 °F at 0.01 mmHg (NTP, 1992) · BP: 120 °C at 0.01 mm Hg
Melting point: 15 °C at 101.325 kPa
Solubility: less than 1 mg/mL at 66 °F (NTP, 1992) · In distilled water, 500 mg/L at 25 °C
Density: 1.04 at 60.3 °F (NTP, 1992) - Denser than water, will sink · 1.03
Stability: Stable under recommended storage conditions.
Viscosity: 48.04 sq mm.s at 20 °C, 17.94 sq mm.s at 30 °C · 48..04 ㎡/s(20℃)
pH: pH = 3.4
Melting/freezing point: &amp, lt, 25 ℃
Initial boiling point and range: 120 ℃
Flash point: 127 ℃(Closed cup)
Vapour pressure: 0.0000368 ㎜Hg(at 25℃)
Water solubility: 500 ㎎/ℓ(at 25℃)
Relative density: 1.04 (15°C)
n-Octanol/water partition coefficient (Kow): 2.45
Molecular weight: 213.340

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 81 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Preservative66
Biocide14
Antioxidant1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

7 skin studies and 2 eye studies are on record.

Classed as highly irritating1Classed as moderate1

The studies disagree (the most common conclusion covers 50%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 9 studies

Skin Corr. 1B
Skin Irritation · Authoritative
Category 8.2C (Category 1C)
Skin Irritation · Read Across
Category 6.5B (Category 1)
Skin Sensitization · Read Across
Sh
Skin Sensitization · Authoritative
Skin Sens. 1
Skin Sensitization · Authoritative
Category 1A
Skin Sensitization · Screening
Category 1
Skin Irritation · Screening
Category 8.3A (Category 1)
Eye Irritation · Read Across
Category 1
Eye Irritation · Screening