Octhilinone is a member of the class of 1,2-thiazole that is 1,2-thiazol-3-one substituted on the nitrogen (position 2) by an octyl group.
定义
美国FDA 物质登记 · UNII 4LFS24GD0V · 登记名称 OCTHILINONE · 单一化学物质
Octhilinone is a member of the class of 1,2-thiazole that is 1,2-thiazol-3-one substituted on the nitrogen (position 2) by an octyl group. A fungicide and antibacterial agent, it is used for treatment of canker and other fungal and bacterial diseases in fruit trees. It is no longer approved for use within the European Union. It has a role as an antibacterial agent, a xenobiotic, an environmental contaminant and an antifungal agrochemical.
来源: PubChem
化妆品中的作用
安全与法规参考
韩国有毒物质 GHS 分类: 危险 · H302 (第4类) · H330 (第2类) · H314 (第1类) · 另有 5 项
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
- CAS No.化学物质登记号
- 26530-20-1
- EC No.欧盟化学品目录编号
- 247-761-7
- DTXSID美国EPA化学品编号
- DTXSID1025805
- DTXCID美国EPA化合物编号
- DTXCID105805
- IUPAC
- 2-Octyl-1,2-thiazol-3(2H)-one
- 分子式
- C11H19NOS
- 分子量
- 213.34 g/mol
实测物性
- 性状
- 2-octyl-3-isothiazolone is a clear dark amber liquid. Used as a fungicide. · Clear dark amber liquid, [CAMEO]
- 气味
- Very weak, sharp smell
- 沸点
- 248 °F at 0.01 mmHg (NTP, 1992) · BP: 120 °C at 0.01 mm Hg
- 熔点
- 15 °C at 101.325 kPa
- 溶解性
- less than 1 mg/mL at 66 °F (NTP, 1992) · In distilled water, 500 mg/L at 25 °C
- 密度
- 1.04 at 60.3 °F (NTP, 1992) - Denser than water, will sink · 1.03
- 稳定性
- Stable under recommended storage conditions.
- 黏度
- 48.04 sq mm.s at 20 °C, 17.94 sq mm.s at 30 °C · 48..04 ㎡/s(20℃)
- pH
- pH = 3.4
- 熔点/凝固点
- &, lt, 25 ℃
- 初沸点和沸程
- 120 ℃
- 闪点
- 127 ℃(Closed cup)
- 蒸气压
- 0.0000368 ㎜Hg(at 25℃)
- 溶解度
- 500 ㎎/ℓ(at 25℃)
- 比重
- 1.04 (15°C)
- 正辛醇/水分配系数（Kow）
- 2.45
- 分子量
- 213.340
这是对物质本身测得的数值。韩国安全保健公团（KOSHA）的资料仅供编写和审核安全数据表参考，并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 81 款产品的用途。其中包括化妆品以外的产品，排在前几行的即为该成分的主要用途。
- Preservative66
- Biocide14
- Antioxidant1
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 7 项、眼部试验 2 项。
各项试验结论不一（最多的结论占 50%），因此不能断定该成分有刺激性。 这是对原料本身的试验记录，与成品中所含浓度下的刺激性不同。
查看全部 9 项试验
- Skin Corr. 1B
Skin Irritation · Authoritative - Category 8.2C (Category 1C)
Skin Irritation · Read Across - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Sh
Skin Sensitization · Authoritative - Skin Sens. 1
Skin Sensitization · Authoritative - Category 1A
Skin Sensitization · Screening - Category 1
Skin Irritation · Screening - Category 8.3A (Category 1)
Eye Irritation · Read Across - Category 1
Eye Irritation · Screening
来源: 美国EPA CompTox
相关文献
- Sofa, So Good? Multifactorial Leather Sofa Dermatitis due to Octylisothiazolinone, Potassium Dichromate and Shellac. · 2026
- Allergic contact dermatitis caused by octylisothiazolinone in a leather car seat: Case report and emergence of octylisothiazolinones in leather goods in Switzerland · 2022
- PEG‐45/dodecyl glycol co‐polymer and bis‐diglyceryl polyacyladipate‐2: Two culprits responsible of an allergic contact dermatitis to a lip balm · 2021
- Current prevalence and relevance of positive patch test reactions to cosmetic and noncosmetic isothiazolinones in the UK · 2021
- Patterns of concomitant allergic reactions in patients suggest cross‐sensitization between octylisothiazolinone and methylisothiazolinone · 2017