Oleamide is a fatty amide derived from oleic acid.
Definition
Oleamide is a fatty amide derived from oleic acid. It has a role as a plant metabolite and a human metabolite.
Source: PubChem
US FDA substance register · UNII 7L25QK8BWO · registered name OLEAMIDE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 3322-62-1
- CAS No.chemical registry number
- 301-02-0
- EC No.EU chemical inventory number
- 931-801-1
- EC No.EU chemical inventory number
- 206-103-9
- DTXSIDUS EPA chemical ID
- DTXSID6027137
- DTXCIDUS EPA compound ID
- DTXCID607137
- IUPAC
- (9Z)-Octadec-9-enamide
- Molecular formula
- C18H35NO
- Molecular weight
- 281.484 g/mol
Measured properties
- Appearance
- Large Crystals, Dry Powder, Liquid, Other Solid · Ivory-colored solid, [HSDB]
- Melting point
- 76 °C · 102 - 104 °C
- Solubility
- INSOL IN WATER, SOL IN ETHER, HOT ALCOHOL
- Density
- 0.94
- Colour
- white
- Melting/freezing point
- 74 ℃
- Initial boiling point and range
- &, gt, 200 ℃
- Flash point
- 210 ℃
- Vapour pressure
- (&, lt, 0.75 mmHg @ 20 °C)
- Water solubility
- 0.04591 ㎎/ℓ
- n-Octanol/water partition coefficient (Kow)
- 3
- Molecular weight
- 281.48
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 47 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Lubricating agent16
- Anti-adhesive/cohesive16
- Processing aids not otherwise specified4
- Surface modifier2
- Anti-slip agent2
- Corrosion inhibitor1
- Viscosity modifier1
- Hardener1
4 other uses
- Adhesion/cohesion promoter1
- Wetting agent (non-aqueous)1
- Anti-static agent1
- Opacifer1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- Classification not possible
Skin Sensitization · Screening - SkinSens1
Skin Sensitization · QSAR Predicted - Not classified
Skin Irritation · Screening - Category 2B
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- Anti-acne and anti-hyperpigmentation potential of selected South African bryophytes with identification of oleamide as a lead compound · 2025
- A Comprehensive Analysis of Chemical Composition and Anti-Inflammatory Effects of Cassava Leaf Extracts in Two Varieties in Manihot esculenta Crantz · 2025
- Effective Icephobicity of Silicone Oil-Infused Oleamide–Polydimethylsiloxane with Enhanced Lubrication Lifetime · 2022
- Comparison of Growth and Chemical Profile of Diatom Skeletonema grevillei in Bioreactor and Incubation-Shaking Cabinet in Two Growth Phases · 2022
- Antiallergic Activity of Ethanol Extracts of Arctium lappa L. Undried Roots and Its Active Compound, Oleamide, in Regulating FcεRI-Mediated and MAPK Signaling in RBL-2H3 Cells. · 2016
Linked databases 17
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese