Definition
Oleuropein is the organic compound that conforms to the formula:
US FDA substance register · UNII 2O4553545L · registered name OLEUROPEIN · single chemical substance
Oleuropein is a secoiridoid glycoside that is the methyl ester of 3,4-dihydro-2H-pyran-5-carboxylic acid which is substituted at positions 2, 3, and 4 by hydroxy, ethylidene, and carboxymethyl groups, respectively and in which the anomeric hydroxy group at position 2 has been converted into its beta-D-glucoside and the carboxylic acid moiety of the carboxymethyl substituent has been converted to the corresponding 3,4-dihydroxyphenethyl ester (the 2S,3E,4S stereoisomer). The most important phenolic compound present in olive cultivars. It has a role as an antioxidant, an antineoplastic agent, an antihypertensive agent, a radical scavenger, a nutraceutical, an anti-inflammatory agent, an apoptosis inducer, a NF-kappaB inhibitor and a plant metabolite. It is a beta-D-glucoside, a methyl ester, a member of pyrans, a member of catechols, a secoiridoid glycoside and a diester.
Source: PubChem
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name オレウロペイン: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 32619-42-4
- EC No.EU chemical inventory number
- 215-129-6
- DTXSIDUS EPA chemical ID
- DTXSID60905103
- DTXCIDUS EPA compound ID
- DTXCID401334206
- IUPAC
- Methyl (2S,3E,4S)-4-{2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl}-3-ethylidene-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-2H-pyran-5-carboxylate
- Molecular formula
- C25H32O13
- Molecular weight
- 540.518 g/mol
What products actually use it for
What the 4 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Antioxidant1
- Hair waving or straightening (EPA)1
- Hair fixative (EPA)1
- Softener and conditioner1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 1 studies
- SkinIrr2
Skin Irritation · QSAR Predicted
Source: US EPA CompTox dashboard
Related literature
- Antiaging Effects of Oleuropein Combined with Helichrysum Italicum or Kumquat Essential Oils in Cosmetic Lotions · 2021
- Oleuropein Degradation Kinetics in Olive Leaf and Its Aqueous Extracts · 2021
- The Effect of Oleuropein on the Treatment of Allergic Rhinitis · 2024
- Oleuropein and skin cancer · 2021
- Characterization of compounds and quantitative analysis of oleuropein in commercial olive leaf extracts · 2021
Linked databases 15
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese