Oridonin is an organic heteropentacyclic compound and ent-kaurane diterpenoid with formula C20H28O6 isolated from the leaves of the medicinal herb Rabdosia rubescens.
Definition
US FDA substance register · UNII 0APJ98UCLQ · registered name ORIDONIN · single chemical substance
Oridonin is an organic heteropentacyclic compound and ent-kaurane diterpenoid with formula C20H28O6 isolated from the leaves of the medicinal herb Rabdosia rubescens. It has a role as an antibacterial agent, an antineoplastic agent, an angiogenesis inhibitor, an anti-asthmatic agent, an apoptosis inducer and a plant metabolite. It is a secondary alcohol, an ent-kaurane diterpenoid, an organic heteropentacyclic compound, an enone and a cyclic hemiketal.
Source: PubChem
Oridonin is the organic compound that conforms to the formula:
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name オリドニン: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 28957-04-2
- EC No.EU chemical inventory number
- 631-100-8
- DTXSIDUS EPA chemical ID
- DTXSID201021760
- DTXCIDUS EPA compound ID
- DTXCID801506730
- IUPAC
- (14R)-1alpha,6beta,7beta,14-Tetrahydroxy-5beta,8alpha,9beta,10alpha,13alpha-7,20-epoxykaur-16-en-15-one
- Molecular formula
- C20H28O6
- Molecular weight
- 364.438 g/mol
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner1
Source: US EPA CompTox dashboard
Related literature
- Research progress and molecular mechanism of oridonin in the treatment of malignant melanoma · 2025
- An H₂S-releasing oridonin derivative protects HaCaT cells against metabolic stress via PI3K/AKT/Nrf2 signaling. · 2026
- An Insight into the Anti-Angiogenic and Anti-Metastatic Effects of Oridonin: Current Knowledge and Future Potential · 2021
- Oridonin enhances in vitro anticancer effects of lentinan in SMMC-7721 human hepatoma cells through apoptotic genes. · 2017
- Oridonin inhibited transplant rejection in mice · 2013
Linked databases 14
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata