Isoambrettolide is a macrolide.
Definition
US FDA substance register · UNII 0DI2GU512F · registered name ISOAMBRETTOLIDE · mixture
Isoambrettolide is a macrolide.
Source: PubChem
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 28645-51-4
- EC No.EU chemical inventory number
- 249-120-7
- DTXSIDUS EPA chemical ID
- DTXSID3051965
- DTXCIDUS EPA compound ID
- DTXCID6030528
- IUPAC
- 1-Oxacycloheptadec-10-en-2-one
- Molecular formula
- C16H28O2
- Molecular weight
- 252.398 g/mol
Measured properties
- Appearance
- CBI · Clear colourless or pale yellow liquid, Sweet musky fruity aroma
- Boiling point
- 185.00 to 190.00 °C. @ 16.00 mm Hg · 1.5-1.6 °C (0.1 mm Hg)
- Solubility
- Soluble in non-polar solvents, insoluble in water · Soluble (in ethanol)
- Density
- 0.949-0.957
- Initial boiling point and range
- 399.2 ℃((760 mmHg))
- Flash point
- 168.2 ℃
- Relative density
- 0.893 g/cm³
- Molecular weight
- 252.39
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 25 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance21
- Flavouring and nutrient2
- Deodorizer2
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
5 skin studies and 1 eye studies are on record.
The studies disagree (the most common conclusion covers 20%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 6 studies
- Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: Open epicutaneous test was conducted to evaluate the skin sensitization potential of o-6-Hexadecenlactone on Guinea Pigs. - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: Human Repeated Insult Patch Test - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: Skin sensitization study was conducted to evaluate the toxic nature of the test compound Ambrettolide - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: Skin sensitization potential of the test compound o-6-Hexadecenlactone was studied in vivo on 178 human patients - Not likely to be sensitizing
skin sensitisation · Screening · according to other guideline: Skin sensitization potential of the test compound o-6-Hexadecenlactone was studied in vivo on humans - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: Eye irritation study was conducted on rabbits to evaluate the irritation potential of the test compound Oxacycloheptadec-10-ene-2-one according to
Source: US EPA CompTox dashboard
Linked databases 12
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- PubChem 2
- UniChem cross-reference IDs 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata 2