Oxyquinoline sulfate is a polymer.
Definition
Oxyquinoline sulfate is a polymer.
Source: PubChem
US FDA substance register · UNII 61VUG75Y3P · registered name OXYQUINOLINE SULFATE · single chemical substance
Oxyquinoline Sulfate is the salt of oxyquinoline and sulfuric acid. It conforms to the formula:
Cosmetic roles
Safety & regulatory references
- Restricted or banned
- Argentina · Brazil · China · European Union · South Korea · Taiwan
- Restricted
- European Union · United Kingdom
Source: MFDS (Korea) cosmetic regulatory information · EU Cosmetics Regulation · UK cosmetics regulations (OPSS)
ASEAN
- Field of application and/or use : (a) Stabilizer for hydrogen peroxide in rinse-off hair care preparations. (b) Stabilizer for hydrogen peroxide in non-rinse-off hair-care preparations.
- Maximum authorised concentration in the finished cosmetic product : (a) 0.3% calculated as base (b) 0.03% calculated as base
Canada
- Conditions of Use by product type : (a) As stabilizers for hydrogen peroxide in rinse-off hair products (b) As stabilizers for hydrogen peroxide in leave-on hair products
- Maximum Concentration Permitted : (a) 0.3% (b) 0.03%
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex III (restricted substances), entry 51 · maximum concentration (a) (0,3 % as base) (b) (0,03 % as base) · applies to (a) Stabilizer for hydrogen peroxide in rinse-off hair products (b) Stabilizer for hydrogen peroxide in leave-on hair products
Restriction II/395 III/51
Source: EU CosIng ingredient list
Reviewed by CIR: Final Amended Report on the Safety of Oxyquinoline and Oxyquinoline Sulfate as used in Cosmetics
Reviewed by CIR: Final Report on the Safety Assessment of Oxyquinoline and Oxyquinoline Sulfate
CIR reviewed this ingredient and flagged its status as: Insufficient Data Announcement: Amended Safety Assessment of Oxyquinoline and Oxyquinoline Sulfate as Used in Cosmetics (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 134-31-6
- EC No.EU chemical inventory number
- 205-137-1
- DTXSIDUS EPA chemical ID
- DTXSID6025436
- DTXCIDUS EPA compound ID
- DTXCID605436
- IUPAC
- Sulfuric acid--quinolin-8-ol (1/2)
- Molecular formula
- C18H16N2O6S
- Molecular weight
- 388.39 g/mol
Measured properties
- Appearance
- 8-hydroxyquinoline sulfate is a pale yellow to yellow crystalline powder with a slight saffron odor. Burning taste. (NTP, 1992) · Light yellow solid with mild odor of saffron, [Merck Index] Yellow crystalline solid, [Sigma-Aldrich MSDS]
- Boiling point
- 267 °C @760 [mm Hg]
- Melting point
- 333 to 360 °F (NTP, 1992)
- Solubility
- greater than or equal to 100 mg/mL at 66 °F (NTP, 1992)
- Density
- 1.034 @ 20°C
- pH
- 2.7 (at 20 °C)
- Melting/freezing point
- 183.74 ℃
- Initial boiling point and range
- 267 ℃(at 760 mmHg)
- Flash point
- 143.1 ℃
- Vapour pressure
- (8.34E-14 mmHg at 25 °C)
- Water solubility
- 1000 g/ℓ(at 20 °C)
- Vapour density
- 1.26 (g/cm3)
- n-Octanol/water partition coefficient (Kow)
- 4.30880
- Molecular weight
- 388.394
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 6 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Biocide3
- Emulsifier2
- Chelating agent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 1 studies
- Category 6.3B (Category 3)
Skin Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- Final Report on the Safety Assessment of Oxyquinoline and Oxyquinoline Sulfate · 1992
- Final Amended Report on the Safety Assessment of Oxyquinoline and Oxyquinoline Sulfate as Used in Cosmetics1 · 2006
- Skin Infections Respond to Hydrocortisone + Oxyquinoline Sulfate · 1987
- [Study of a drug combination with contraceptive, antibacterial, antimycotic and prophylactic action, for topical use in venereal diseases. 4. Effect of the combination of oxyquinoline sulfate, copper sulfate and lactic acid on Trichomonas vaginalis and on Candida albicans in vivo]. · 1980
- [Study of a topical antibacterial, contraceptive, antifungal and anti-venereal pharmacological combination. III. Post-coital test of the spermicidal action of a combination of oxyquinoline sulfate, copper sulfate and lactic acid]. · 1979
Linked databases 21
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU restricted substances (Annex III)
- Health Canada Cosmetic Ingredient Hotlist
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3
- PubChem 2
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3 4
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata