Quinolin-8-ol is a monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8.
Definition
Quinolin-8-ol is a monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes. It has a role as an antibacterial agent, an iron chelator, an antiseptic drug and an antifungal agrochemical. It derives from a hydride of a quinoline.
Source: PubChem
US FDA substance register · UNII 5UTX5635HP · registered name Oxyquinoline · single chemical substance
Oxyquinoline is the heterocyclic compound that conforms to the formula:
Cosmetic roles
Safety & regulatory references
- Restricted or banned
- Argentina · Brazil · China · European Union · South Korea · Taiwan
Source: MFDS (Korea) cosmetic regulatory information
ASEAN
- Field of application and/or use : (a) Stabilizer for hydrogen peroxide in rinse-off hair care preparations. (b) Stabilizer for hydrogen peroxide in non-rinse-off hair-care preparations.
- Maximum authorised concentration in the finished cosmetic product : (a) 0.3% calculated as base (b) 0.03% calculated as base
Canada
- Conditions of Use by product type : (a) As stabilizers for hydrogen peroxide in rinse-off hair products (b) As stabilizers for hydrogen peroxide in leave-on hair products
- Maximum Concentration Permitted : (a) 0.3% (b) 0.03%
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Restriction II/395
Source: EU CosIng ingredient list
Reviewed by CIR: Final Report on the Safety Assessment of Oxyquinoline and Oxyquinoline Sulfate
Reviewed by CIR: Final Amended Report on the Safety of Oxyquinoline and Oxyquinoline Sulfate as used in Cosmetics
CIR reviewed this ingredient and flagged its status as: Insufficient Data Announcement: Amended Safety Assessment of Oxyquinoline and Oxyquinoline Sulfate as Used in Cosmetics (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 148-24-3
- EC No.EU chemical inventory number
- 205-711-1
- DTXSIDUS EPA chemical ID
- DTXSID5020730
- DTXCIDUS EPA compound ID
- DTXCID30730
- IUPAC
- Quinolin-8-ol
- Molecular formula
- C9H7NO
- Molecular weight
- 145.161 g/mol
Measured properties
- Appearance
- 8-hydroxyquinoline appears as white to off-white or faintly yellow crystalline powder. Phenolic odor. (NTP, 1992) · White solid with a phenolic odor, [Hawley] White or tan powder, [MSDSonline]
- Odour
- Phenolic odor
- Boiling point
- 513 °F at 760 mmHg (NTP, 1992) · 267
- Melting point
- 169 °F (NTP, 1992) · 76
- Solubility
- less than 1 mg/mL at 61 °F (NTP, 1992) · Insoluble
- Density
- 1.034 at 408 °F (NTP, 1992) - Denser than water, will sink · 1.034 @ 20 °C
- Stability
- DARKENS WHEN EXPOSED TO LIGHT.
- Dissociation constant
- 5.017 · pKa 5.017, Ka 1.21X10-6 at 20 °C
- Colour
- white
- Melting/freezing point
- 75.5 ℃
- Initial boiling point and range
- 267 ℃
- Flammability (solid, gas)
- combustible
- Vapour pressure
- 0.00166 ㎜Hg (@ 25 ℃)
- Water solubility
- 556 ㎎/ℓ (@ 20 ℃)
- Vapour density
- 5.01
- Relative density
- 1.034 (@ 20 ℃)
- n-Octanol/water partition coefficient (Kow)
- 2.02
- Molecular weight
- 145.17
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Stabilizing agent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
6 skin studies and 4 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 10 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) 28 Jul 2015 according to - SkinSens1
Skin Sensitization · QSAR Predicted - Skin Sens. 1
Skin Sensitization · Authoritative - Category 6.3B (Category 3)
Skin Irritation · Read Across - Not classified
Skin Irritation · Screening - Classification not possible
Skin Sensitization · Screening - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Category 2B
Eye Irritation · Screening - Eye Dam. 1
Eye Irritation · Authoritative - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) 02 Oct 2012 according to
Source: US EPA CompTox dashboard
Related literature
- Acremonium species skin infection in a female French bulldog · 2022
- Experimental study of new 3-(2-R1-6-R2-4-oxyquinoline-3(4H)-yl)alkyl (alkaryl-, aryl) carboxylic acid derivative (PC-66 compound) · 2017
- Unusual cause of severe toxic methemoglobinemia in an infant: a case report · 2010
- Final Amended Report on the Safety Assessment of Oxyquinoline and Oxyquinoline Sulfate as Used in Cosmetics1 · 2006
- Systematic review of antimicrobial agents used for chronic wounds · 2001
Linked databases 23
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- Health Canada Cosmetic Ingredient Hotlist
- IARC carcinogen classification
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3 4
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- US National Toxicology Program reports
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese