Quinolin-8-ol is a monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8.
定义
Quinolin-8-ol is a monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes. It has a role as an antibacterial agent, an iron chelator, an antiseptic drug and an antifungal agrochemical. It derives from a hydride of a quinoline.
来源: PubChem
美国FDA 物质登记 · UNII 5UTX5635HP · 登记名称 Oxyquinoline · 单一化学物质
Oxyquinoline is the heterocyclic compound that conforms to the formula:
化妆品中的作用
安全与法规参考
- 限用·禁用
- 阿根廷 · 巴西 · 韩国 · 欧盟 · 台湾 · 中国
来源: 韩国食药处 化妆品法规信息
东盟
- Field of application and/or use : (a) Stabilizer for hydrogen peroxide in rinse-off hair care preparations. (b) Stabilizer for hydrogen peroxide in non-rinse-off hair-care preparations.
- Maximum authorised concentration in the finished cosmetic product : (a) 0.3% calculated as base (b) 0.03% calculated as base
加拿大
- Conditions of Use by product type : (a) As stabilizers for hydrogen peroxide in rinse-off hair products (b) As stabilizers for hydrogen peroxide in leave-on hair products
- Maximum Concentration Permitted : (a) 0.3% (b) 0.03%
来源: 韩国食药处 化妆品法规信息
未列入韩国有毒物质 GHS 分类 · 现有化学物质
Restriction II/395
来源: 欧盟 CosIng 成分清单
Reviewed by CIR: Final Report on the Safety Assessment of Oxyquinoline and Oxyquinoline Sulfate
来源: 美国CIR 安全性评估
Reviewed by CIR: Final Amended Report on the Safety of Oxyquinoline and Oxyquinoline Sulfate as used in Cosmetics
来源: 美国CIR 安全性评估
CIR reviewed this ingredient and flagged its status as: Insufficient Data Announcement: Amended Safety Assessment of Oxyquinoline and Oxyquinoline Sulfate as Used in Cosmetics (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).
来源: 美国CIR 安全性评估
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
- CAS No.化学物质登记号
- 148-24-3
- EC No.欧盟化学品目录编号
- 205-711-1
- DTXSID美国EPA化学品编号
- DTXSID5020730
- DTXCID美国EPA化合物编号
- DTXCID30730
- IUPAC
- Quinolin-8-ol
- 分子式
- C9H7NO
- 分子量
- 145.161 g/mol
实测物性
- 性状
- 8-hydroxyquinoline appears as white to off-white or faintly yellow crystalline powder. Phenolic odor. (NTP, 1992) · White solid with a phenolic odor, [Hawley] White or tan powder, [MSDSonline]
- 气味
- Phenolic odor
- 沸点
- 513 °F at 760 mmHg (NTP, 1992) · 267
- 熔点
- 169 °F (NTP, 1992) · 76
- 溶解性
- less than 1 mg/mL at 61 °F (NTP, 1992) · Insoluble
- 密度
- 1.034 at 408 °F (NTP, 1992) - Denser than water, will sink · 1.034 @ 20 °C
- 稳定性
- DARKENS WHEN EXPOSED TO LIGHT.
- 解离常数
- 5.017 · pKa 5.017, Ka 1.21X10-6 at 20 °C
- 颜色
- 白色
- 熔点/凝固点
- 75.5 ℃
- 初沸点和沸程
- 267 ℃
- 易燃性(固体、气体)
- 可燃
- 蒸气压
- 0.00166 ㎜Hg (@ 25 ℃)
- 溶解度
- 556 ㎎/ℓ (@ 20 ℃)
- 蒸气密度
- 5.01
- 比重
- 1.034 (@ 20 ℃)
- 正辛醇/水分配系数(Kow)
- 2.02
- 分子量
- 145.17
这是对物质本身测得的数值。韩国安全保健公团(KOSHA)的资料仅供编写和审核安全数据表参考,并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
刺激与致敏试验记录
记录有皮肤试验 6 项、眼部试验 4 项。
试验结论基本一致(100%)。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。
查看全部 10 项试验
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) 28 Jul 2015 according to - SkinSens1
Skin Sensitization · QSAR Predicted - Skin Sens. 1
Skin Sensitization · Authoritative - Category 6.3B (Category 3)
Skin Irritation · Read Across - Not classified
Skin Irritation · Screening - Classification not possible
Skin Sensitization · Screening - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Category 2B
Eye Irritation · Screening - Eye Dam. 1
Eye Irritation · Authoritative - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) 02 Oct 2012 according to
来源: 美国EPA CompTox
相关文献
- Acremonium species skin infection in a female French bulldog · 2022
- Experimental study of new 3-(2-R1-6-R2-4-oxyquinoline-3(4H)-yl)alkyl (alkaryl-, aryl) carboxylic acid derivative (PC-66 compound) · 2017
- Unusual cause of severe toxic methemoglobinemia in an infant: a case report · 2010
- Final Amended Report on the Safety Assessment of Oxyquinoline and Oxyquinoline Sulfate as Used in Cosmetics1 · 2006
- Systematic review of antimicrobial agents used for chronic wounds · 2001
关联数据库 23
- 澳大利亚工业化学品名录(AICIS)
- 东盟化妆品指令
- 韩国安全保健公团 安全数据表
- 韩国食药处 化妆品法规信息 2 3
- 韩国有毒物质 GHS 信息(环境公团)
- 加拿大禁用·限用成分清单
- 美国CIR 安全性评估 2 3 4
- 美国EPA 化学品数据库(DSSTox)
- 美国EPA CompTox 2
- 美国FDA 物质登记(GSRS)
- 美国FDA 物质识别码(UNII)
- 美国NTP 毒理学报告
- 欧盟 CosIng 成分清单 2
- 中国已使用化妆品原料目录(IECIC)
- ChEBI
- ChEMBL
- IARC 致癌性分类
- NIST 化学网络手册
- PubChem 2
- Tlooto 学术文献检索 2 3 4 5
- UniChem 化学物质统一 ID
- Wikidata
- Wikipedia · 韩语 · 英语 · 日语 · 中文