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成分词典

成分词典

OXYQUINOLINE

Quinolin-8-ol is a monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8.

分子结构

定义

Quinolin-8-ol is a monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes. It has a role as an antibacterial agent, an iron chelator, an antiseptic drug and an antifungal agrochemical. It derives from a hydride of a quinoline.

来源: PubChem

美国FDA 物质登记 · UNII 5UTX5635HP · 登记名称 Oxyquinoline · 单一化学物质

来源: 美国FDA 物质识别码(UNII)

Oxyquinoline is the heterocyclic compound that conforms to the formula:

化妆品中的作用

抑制微生物生长ANTIMICROBIAL螯合金属离子防止变质CHELATING

安全与法规参考

限用·禁用
阿根廷 · 巴西 · 韩国 · 欧盟 · 台湾 · 中国

来源: 韩国食药处 化妆品法规信息

东盟

  • Field of application and/or use : (a) Stabilizer for hydrogen peroxide in rinse-off hair care preparations. (b) Stabilizer for hydrogen peroxide in non-rinse-off hair-care preparations.
  • Maximum authorised concentration in the finished cosmetic product : (a) 0.3% calculated as base (b) 0.03% calculated as base

加拿大

  • Conditions of Use by product type : (a) As stabilizers for hydrogen peroxide in rinse-off hair products (b) As stabilizers for hydrogen peroxide in leave-on hair products
  • Maximum Concentration Permitted : (a) 0.3% (b) 0.03%

来源: 韩国食药处 化妆品法规信息

未列入韩国有毒物质 GHS 分类 · 现有化学物质

来源: 韩国有毒物质 GHS 信息(环境公团)

Restriction II/395

来源: 欧盟 CosIng 成分清单

Reviewed by CIR: Final Report on the Safety Assessment of Oxyquinoline and Oxyquinoline Sulfate

来源: 美国CIR 安全性评估

Reviewed by CIR: Final Amended Report on the Safety of Oxyquinoline and Oxyquinoline Sulfate as used in Cosmetics

来源: 美国CIR 安全性评估

CIR reviewed this ingredient and flagged its status as: Insufficient Data Announcement: Amended Safety Assessment of Oxyquinoline and Oxyquinoline Sulfate as Used in Cosmetics (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).

来源: 美国CIR 安全性评估

详细资料——标示名称、识别编号、物性、试验记录、文献

别名和识别信息

OXYQUINOLINEINCI옥시퀴놀린韩国标示名称(食药处标准名)8-Quinolinol同义名
CAS No.化学物质登记号
148-24-3
EC No.欧盟化学品目录编号
205-711-1
DTXSID美国EPA化学品编号
DTXSID5020730
DTXCID美国EPA化合物编号
DTXCID30730
IUPAC
Quinolin-8-ol
分子式
C9H7NO
分子量
145.161 g/mol

实测物性

性状
8-hydroxyquinoline appears as white to off-white or faintly yellow crystalline powder. Phenolic odor. (NTP, 1992) · White solid with a phenolic odor, [Hawley] White or tan powder, [MSDSonline]
气味
Phenolic odor
沸点
513 °F at 760 mmHg (NTP, 1992) · 267
熔点
169 °F (NTP, 1992) · 76
溶解性
less than 1 mg/mL at 61 °F (NTP, 1992) · Insoluble
密度
1.034 at 408 °F (NTP, 1992) - Denser than water, will sink · 1.034 @ 20 °C
稳定性
DARKENS WHEN EXPOSED TO LIGHT.
解离常数
5.017 · pKa 5.017, Ka 1.21X10-6 at 20 °C
颜色
白色
熔点/凝固点
75.5 ℃
初沸点和沸程
267 ℃
易燃性(固体、气体)
可燃
蒸气压
0.00166 ㎜Hg (@ 25 ℃)
溶解度
556 ㎎/ℓ (@ 20 ℃)
蒸气密度
5.01
比重
1.034 (@ 20 ℃)
正辛醇/水分配系数(Kow)
2.02
分子量
145.17

这是对物质本身测得的数值。韩国安全保健公团(KOSHA)的资料仅供编写和审核安全数据表参考,并非原料商品的规格。

来源: PubChem · 韩国安全保健公团 安全数据表

产品实际使用的用途

这是向美国 EPA 申报含该成分的 1 款产品的用途。其中包括化妆品以外的产品,排在前几行的即为该成分的主要用途。

  • Stabilizing agent1

来源: 美国EPA CompTox

刺激与致敏试验记录

记录有皮肤试验 6 项、眼部试验 4 项。

归类为中等1 项

试验结论基本一致(100%)。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。

查看全部 10 项试验
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) 28 Jul 2015 according to
  • SkinSens1
    Skin Sensitization · QSAR Predicted
  • Skin Sens. 1
    Skin Sensitization · Authoritative
  • Category 6.3B (Category 3)
    Skin Irritation · Read Across
  • Not classified
    Skin Irritation · Screening
  • Classification not possible
    Skin Sensitization · Screening
  • Category 6.4A (Category 2A)
    Eye Irritation · Read Across
  • Category 2B
    Eye Irritation · Screening
  • Eye Dam. 1
    Eye Irritation · Authoritative
  • Corrosive or Irritation Persists for > 21 days
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) 02 Oct 2012 according to

来源: 美国EPA CompTox

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