Ingredient Dictionary

P-AMINOPHENOL

4-aminophenol is an amino phenol (one of the three possible isomers) which has the single amino substituent located para to the phenolic -OH group.

Korean limit: 0.9%

P-AMINOPHENOL Molecular structure — Molecular structure

How much products actually contain

No product states its amount yet.

Of the products containing it, 2 list it before the 1% line and 5 after it (usually 1% or less).

Products using this ingredient

7 of 7 confirmed · likeliest to carry enough first

Definition

4-aminophenol is an amino phenol (one of the three possible isomers) which has the single amino substituent located para to the phenolic -OH group. It has a role as a metabolite and an allergen.

Source: PubChem

US FDA substance register · UNII R7P8FRP05V · registered name p-Aminophenol · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Dyes hairHAIR DYEING

Safety & regulatory references

Restricted: South Korea · Taiwan · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · Taiwan FDA cosmetic regulations · UK cosmetics regulations (OPSS)

ASEAN

Field of application and/or use : Hair dye substance in oxidative hair dye products
Maximum authorised concentration in the finished cosmetic product : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.9%
Other limitations and requirements : The direction for use “wear suitable gloves” must be included in label or leaflet text.
Conditions of use and warning which must be printed on the labels : The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows

China

Maximum concentration : 0.5%

European Union

Product Type, body parts : Hair dye substance in oxidative hair dye products
Other : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0,9 %
Wording of conditions of use and warnings : To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past."

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex III (restricted substances), entry 272 · applies to (a) Hair dye substance in oxidative hair dye products (b) Products intended for colouring eyelashes

Source: EU restricted substances (Annex III)

Restriction III/272 - (EC) No 1197/2013 · SCCS opinion: Opinion on p-Aminophenol

Source: EU CosIng ingredient list

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2005/2006

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of p-Aminophenol, m-Aminophenol, and o-Aminophenol

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

P-AMINOPHENOLINCIp-아미노페놀Korean label name (MFDS standard)Phenol, 4-amino-Synonym

CAS No.chemical registry number: 123-30-8
EC No.EU chemical inventory number: 204-616-2
DTXSIDUS EPA chemical ID: DTXSID3024499
DTXCIDUS EPA compound ID: DTXCID504499

IUPAC: 4-Aminophenol
Molecular formula: C6H7NO
Molecular weight: 109.128 g/mol

Measured properties

Appearance: P-aminophenol appears as white or reddish-yellow crystals or light brown powder. Turns violet when exposed to light. (NTP, 1992) · Dry Powder
Boiling point: 543 °F at 760 mmHg (Decomposes) (NTP, 1992) · 284 °C at 760 mm Hg, decomposes, 167 °C at 8.0 mm Hg, 150 °C at 3.0 mm Hg, 130.2 °C at 0.3 mm Hg
Melting point: 367 to 369 °F (NTP, 1992) · 367-369 °F
Solubility: less than 1 mg/mL at 73 °F (NTP, 1992) · Solubility in water: 0.39% at 0 °C, 0.65% at 24 °C, 0.80% at 30 °C, in ethyl methyl ketone: 9.3% at 58.5 °C, in absolute ethanol: 4.5% at 0 °C, practically insoluble in benzene and chloroform
Density: 4-Aminophenol crystals exist in two forms. The alpha form (from alcohol, water, or ethyl acetate) is the more stable and has an orthorhombic pyramidal structure, density 1.290 g/cu cm /alpha-4-Aminophenol/
Stability: Deteriorates under influence of air and light
Dissociation constant: pK1 = 5.48 at 25 °C (conjugate acid) · pK2 = 10.46
Odour: odourless
pH: 8
Flash point: 100 ℃
Water solubility: 0.65 g/100㎖ (24℃)

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Dye3

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

6 skin studies and 3 eye studies are on record.

Classed as highly irritating1Classed as low3

The studies disagree (the most common conclusion covers 25%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 9 studies

Sh
Skin Sensitization · Authoritative
Not classified
Skin Irritation · Screening
Category 1
Skin Sensitization · Screening
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: US Consumer Product Safety Commission (Code of Federal Regulations, Title 16, Section1500.41) according to
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Category 2B
Eye Irritation · Screening
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · EPA OPPTS 870.2400 (Acute Eye Irritation) equivalent or similar to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to