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成分词典

成分词典

P-AMINOPHENOL

4-aminophenol is an amino phenol (one of the three possible isomers) which has the single amino substituent located para to the phenolic -OH group.

韩国限量
0.9%
分子结构

产品中实际含有多少

暂无产品标示该成分含量。

含该成分的产品中,2 款将其列在 1% 线之前,5 款列在之后(通常不超过 1%)。

含有此成分的产品

已确认 7 款中的 7 款 · 按含量充足程度排序

定义

4-aminophenol is an amino phenol (one of the three possible isomers) which has the single amino substituent located para to the phenolic -OH group. It has a role as a metabolite and an allergen.

来源: PubChem

美国FDA 物质登记 · UNII R7P8FRP05V · 登记名称 p-Aminophenol · 单一化学物质

来源: 美国FDA 物质识别码(UNII)

化妆品中的作用

染发HAIR DYEING

安全与法规参考

限用
韩国 · 英国

来源: 东盟化妆品指令 · 欧盟化妆品法规 · 韩国食药处 化妆品法规信息 · 台湾FDA 化妆品成分 · 台湾FDA 化妆品法规 · 英国化妆品法规

东盟

  • Field of application and/or use : Hair dye substance in oxidative hair dye products
  • Maximum authorised concentration in the finished cosmetic product : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.9%
  • Other limitations and requirements : The direction for use “wear suitable gloves” must be included in label or leaflet text.
  • Conditions of use and warning which must be printed on the labels : The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows

台湾

  • ※ 染髮產品之限量標準:係指該成分依產品使用說明書混合後之最高允許使用量。
  • ※ 化粧品之外包裝或容器,應明顯標示本表所列成分之注意事項。因外包裝或容器表面積過小或其他特殊情形致不能標示者,應於標籤、仿單或以其他方式刊載之。
  • ※ 本表所稱之口腔製劑,包含非藥用牙膏、漱口水類及美白牙齒類等化粧品。
  • ※ 化粧品宣稱效能者,須符合化粧品標示宣傳廣告涉及虛偽誇大或醫療效能認定準則規定。
  • 用途 : 使用限制
  • 最大配合量 : 氧化性染髮產品 : 0.9%

中国

  • 最大配合量 : 0.5%

欧盟

  • Product Type, body parts : Hair dye substance in oxidative hair dye products
  • Other : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0,9 %
  • Wording of conditions of use and warnings : To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past."

来源: 韩国食药处 化妆品法规信息

未列入韩国有毒物质 GHS 分类 · 现有化学物质

来源: 韩国有毒物质 GHS 信息(环境公团)

欧盟化妆品法规 附录III(限用物质) 第272项 · 适用 (a) Hair dye sub­stance in oxidat­ive hair dye products (b) Products in­tended for col­ouring eyelashes

来源: 欧盟限用成分(附录III)

Restriction III/272 - (EC) No 1197/2013 · SCCS opinion: Opinion on p-Aminophenol

来源: 欧盟 CosIng 成分清单

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2005/2006

来源: 美国CIR 安全性评估

Reviewed by CIR: Final Report on the Safety Assessment of p-Aminophenol, m-Aminophenol, and o-Aminophenol

来源: 美国CIR 安全性评估

详细资料——标示名称、识别编号、物性、试验记录、文献

别名和识别信息

P-AMINOPHENOLINCIp-아미노페놀韩国标示名称(食药处标准名)Phenol, 4-amino-同义名
CAS No.化学物质登记号
123-30-8
EC No.欧盟化学品目录编号
204-616-2
DTXSID美国EPA化学品编号
DTXSID3024499
DTXCID美国EPA化合物编号
DTXCID504499
IUPAC
4-Aminophenol
分子式
C6H7NO
分子量
109.128 g/mol

实测物性

性状
P-aminophenol appears as white or reddish-yellow crystals or light brown powder. Turns violet when exposed to light. (NTP, 1992) · Dry Powder
沸点
543 °F at 760 mmHg (Decomposes) (NTP, 1992) · 284 °C at 760 mm Hg, decomposes, 167 °C at 8.0 mm Hg, 150 °C at 3.0 mm Hg, 130.2 °C at 0.3 mm Hg
熔点
367 to 369 °F (NTP, 1992) · 367-369 °F
溶解性
less than 1 mg/mL at 73 °F (NTP, 1992) · Solubility in water: 0.39% at 0 °C, 0.65% at 24 °C, 0.80% at 30 °C, in ethyl methyl ketone: 9.3% at 58.5 °C, in absolute ethanol: 4.5% at 0 °C, practically insoluble in benzene and chloroform
密度
4-Aminophenol crystals exist in two forms. The alpha form (from alcohol, water, or ethyl acetate) is the more stable and has an orthorhombic pyramidal structure, density 1.290 g/cu cm /alpha-4-Aminophenol/
稳定性
Deteriorates under influence of air and light
解离常数
pK1 = 5.48 at 25 °C (conjugate acid) · pK2 = 10.46
气味
无臭
pH
8
闪点
100 ℃
溶解度
0.65 g/100㎖ (24℃)

这是对物质本身测得的数值。韩国安全保健公团(KOSHA)的资料仅供编写和审核安全数据表参考,并非原料商品的规格。

来源: PubChem · 韩国安全保健公团 安全数据表

产品实际使用的用途

这是向美国 EPA 申报含该成分的 3 款产品的用途。其中包括化妆品以外的产品,排在前几行的即为该成分的主要用途。

  • Dye3

来源: 美国EPA CompTox

刺激与致敏试验记录

记录有皮肤试验 6 项、眼部试验 3 项。

归类为刺激性高1 项归类为低3 项

各项试验结论不一(最多的结论占 25%),因此不能断定该成分有刺激性。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。

查看全部 9 项试验
  • Sh
    Skin Sensitization · Authoritative
  • Not classified
    Skin Irritation · Screening
  • Category 1
    Skin Sensitization · Screening
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · other guideline: US Consumer Product Safety Commission (Code of Federal Regulations, Title 16, Section1500.41) according to
  • High Frequency of Sensitization
    skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
  • Category 2B
    Eye Irritation · Screening
  • Studies Indicate No Significant Irritation
    eye irritation: in vivo · Screening · EPA OPPTS 870.2400 (Acute Eye Irritation) equivalent or similar to
  • Studies Indicate No Significant Irritation
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to

来源: 美国EPA CompTox

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