P-CHLORO-M-CRESOL

p-Chloro-m-Cresol is the substituted phenol that conforms to the formula:

4-chloro-m-cresol is a hydroxytoluene that is 3-methylphenol which is substituted by a chlorine at position 4. A ryanodine receptor agonist. It has a role as an antimicrobial agent, a disinfectant and a ryanodine receptor agonist. It is a hydroxytoluene and a member of monochlorobenzenes.

Source: PubChem

US FDA substance register · UNII 36W53O7109 · registered name CHLOROCRESOL · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Allowed preservative

United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Japan Standards for Cosmetics · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Argentina · Brazil

• Maximum concentration permitted at final product : 0.2%
• Other limitations and requirements : Prohibited in products intended to come into contact with mucous.

ASEAN

• Maximum authorised concentration in the finished cosmetic product : 0.2%
• Other limitations and requirements : Prohibited in products intended to come into contact with mucous membranes

Canada

• Conditions of Use by product type : (a) Not permitted in cosmetics intended to be used on or around mucosal membranes such as eyes, nose or mouth (b) Other cosmetics
• Maximum Concentration Permitted : (b) 0.1%
• Warnings and Cautionary Statements: (to the effect of) : "Do not use in the area of the eye, mouth or nose"

Taiwan

• 0.2%

Japan

• Maximum amount per 100 g(Maximum amount of ingredient per 100 g) : 0.50(0.50 g)

China

• Maximum concentration : 0.2%

South Korea

• Maximum concentration : 0.04%

European Union

• Product Type, body parts : Not to be used in products applied on mucous membranes
• Maximum concentration in ready for use preparation : 0.2%

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex V (allowed preservatives), entry 24 · maximum concentration 0.2% · applies to Not to be used in products applied on mucous membranes

Source: EU allowed preservatives (Annex V)

Restriction V/24 · Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report on the Safety Assessment of Sodium p-Chloro-m-Cresol, p-Chloro-m-Cresol, Chlorothymol, Mixed Cresols, m-Cresol, o-Cresol, p-Cresol, Isopropyl Cresols, Thymol, o-Cymen-5-ol and Carvacrol

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of p-Chloro-m-Cresol

Source: US Cosmetic Ingredient Review (CIR)