Ingredient Dictionary

P-CHLOROPHENOL

4-chlorophenol is a monochlorophenol substituted at the pare position by a chlorine atom.

Definition

4-chlorophenol is a monochlorophenol substituted at the pare position by a chlorine atom.

Source: PubChem

US FDA substance register · UNII 3DLC36A01X · registered name 4-Chlorophenol · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Inhibits microbial growthANTIMICROBIAL

Safety & regulatory references

Japan

Maximum amount per 100 g (Cosmetics not used for mucosa and to be washed away) : 0.25 g
Maximum amount per 100 g (Cosmetics not used for mucosa and not to be washed away) : 0.25 g

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name クロロフェノール: 本品は、次の化学式で表されるハロゲン化フェノールである。

Source: JCIA labelling names (Japan)

JCIA labelling name ｐ－クロロフェノール: 本品は、次の化学式で表されるハロゲン化フェノールである。

Source: JCIA labelling names (Japan)

Names & identifiers

P-CHLOROPHENOLINCIp-클로로페놀Korean label name (MFDS standard)Phenol, 4-chloro-Synonymｐ－クロロフェノールJapanese labelling nameクロロフェノールJapanese labelling name

CAS No.chemical registry number: 106-48-9
EC No.EU chemical inventory number: 203-402-6
DTXSIDUS EPA chemical ID: DTXSID1021871
DTXCIDUS EPA compound ID: DTXCID201871

IUPAC: 4-Chlorophenol
Molecular formula: C6H5ClO
Molecular weight: 128.56 g/mol

Measured properties

Appearance: P-chlorophenol appears as white crystals with a strong phenol odor. Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible. Used as an intermediate in organic synthesis of dyes and drugs. · White solid, Yellow or pink if not pure, Unpleasant, penetrating odor, [Hawley] Off-white crystalline powder, [MSDSonline]
Odour: Characeteristic phenolic odor · Unpleasant, penetrating odor
Boiling point: 428 °F at 760 mmHg (NTP, 1992) · 220 °C
Melting point: 109.8 to 110.7 °F (NTP, 1992) · 42.8 °C
Solubility: 10 to 50 mg/mL at 59 °F (NTP, 1992) · 2.71 PARTS SOL IN 100 PARTS WATER @ 20 °C
Density: 1.31 at 68 °F (USCG, 1999) - Denser than water, will sink · 1.2238 at 78 °C/4 °C
Stability: Volatile with steam
Viscosity: 5 cP at 50 °C
pH: 1% solution is acidic to litmus
Dissociation constant: pKa = 9.41
Melting/freezing point: 43 ℃
Initial boiling point and range: 220 ℃
Flash point: 121 ℃(c.c.)
Vapour pressure: 13 ㎜Hg (20℃)
Water solubility: 2.71 g/100㎖ (29℃)
Vapour density: 4.44
Relative density: 1.306
n-Octanol/water partition coefficient (Kow): 2.39

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Biocide1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

3 skin studies and 2 eye studies are on record.

Classed as highly irritating1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 5 studies

Skin corrosion/irritation - Category 1
Skin Irritation · Screening
Category 1
Skin Irritation · Screening
Classification not possible
Skin Sensitization · Screening
Serious eye damage/eye irritation - Category 1
Eye Irritation · Screening
Category 1
Eye Irritation · Screening