P-cresol is a cresol that consists of toluene substituted by a hydroxy group at position 4.
产品中实际含有多少
暂无产品标示该成分含量。
含该成分的产品中,1 款将其列在 1% 线之前,4 款列在之后(通常不超过 1%)。
含有此成分的产品
已确认 5 款中的 5 款 · 按含量充足程度排序
定义
P-cresol is a cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals. It has a role as a uremic toxin, an Escherichia coli metabolite and a human metabolite.
来源: PubChem
美国FDA 物质登记 · UNII 1MXY2UM8NV · 登记名称 Paracresol · 单一化学物质
化妆品中的作用
安全与法规参考
- 限用
- 国际香料标准(IFRA)
来源: IFRA 香料标准
韩国有毒物质 GHS 分类: 危险 · H301 (第3类) · H314 (第1类) · H311 (第3类)
加拿大化妆品成分热点清单 · 禁止用于化妆品
来源: 加拿大禁用·限用成分清单
Other restriction: ban substances that deplete the ozone layer
来源: 欧盟 CosIng 成分清单
Reviewed by CIR: Final Report on the Safety Assessment of Sodium p-Chloro-m-Cresol, p-Chloro-m-Cresol, Chlorothymol, Mixed Cresols, m-Cresol, o-Cresol, p-Cresol, Isopropyl Cresols, Thymol, o-Cymen-5-ol and Carvacrol
来源: 美国CIR 安全性评估
CIR reviewed this ingredient and flagged its status as: Insufficient data ingredients with no uses reported to FDA's Voluntary Cosmetic Registration Program (VCRP) (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).
来源: 美国CIR 安全性评估
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
- CAS No.化学物质登记号
- 106-44-5
- EC No.欧盟化学品目录编号
- 203-398-6
- DTXSID美国EPA化学品编号
- DTXSID7021869
- DTXCID美国EPA化合物编号
- DTXCID101869
- IUPAC
- 4-Methylphenol
- 分子式
- C7H8O
- 分子量
- 108.14 g/mol
实测物性
- 性状
- 固体
- 熔点/凝固点
- 35 ℃
- 初沸点和沸程
- 202 ℃
- 闪点
- 86 ℃
- 燃烧或爆炸范围上限/下限
- 1 % (150℃)
- 蒸气压
- 0.147 ㎩ (25℃)
- 溶解度
- 1.9 g/100㎖
- 蒸气密度
- 1
- 比重
- 1.034 (20℃)
- 正辛醇/水分配系数(Kow)
- 1.94
- 自燃温度
- 555 ℃
- 黏度
- 4480000 (25℃)
- 分子量
- 108.13
这是对物质本身测得的数值。韩国安全保健公团(KOSHA)的资料仅供编写和审核安全数据表参考,并非原料商品的规格。
来源: 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 44 款产品的用途。其中包括化妆品以外的产品,排在前几行的即为该成分的主要用途。
- Fragrance21
- Solvent4
- Cleaning agent2
- Flavouring and nutrient2
- Monomers2
- Intermediate2
- Antioxidant1
- Catalyst1
其余用途 9 项
- No specific technical function1
- Biocide1
- Dye1
- Corrosion inhibitor1
- Preservative1
- Photosensitive agent1
- Pharmaceutical (EPA)1
- Processing aids not otherwise specified1
- Surfactant (surface active agent)1
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 7 项、眼部试验 2 项。
试验结论基本一致(100%)。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。
查看全部 9 项试验
- Skin Corr. 1B
Skin Irritation · Authoritative - Classification not possible
Skin Sensitization · Screening - Skin corrosion/irritation - Category 1
Skin Irritation · Screening - Category 1
Skin Irritation · Screening - Skin corrosion - category 1A
Skin Irritation · Screening - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) - Category 8.2C (Category 1C)
Skin Irritation · Read Across - Category 1
Eye Irritation · Screening - Category 8.3A (Category 1)
Eye Irritation · Read Across
来源: 美国EPA CompTox
相关文献
- Lactobacillus gasseri Decreases p-Cresol Levels in Serum and Cecum and Improves Skin Characteristics in Mice Fed with Tyrosine-Rich Diets · 2025
- Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor · 2024
- Effective p-cresol removal through catalytic liquid-phase oxidation under moderate conditions using Pt/CeO2-ZrO2-SnO2/SBA-16 as a catalyst · 2020
- Uremic solutes of indoxyl sulfate and p-cresol enhance protease-activated receptor-2 expression in vitro and in vivo in keratinocytes · 2020
- The uremic molecule p‐cresol is lowered after supplementing the diet of chronic kidney disease patients with fiber · 2013