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Ingredients

Ingredient Dictionary

P-HYDROXYANISOLE

P-methoxyphenol is a member of phenols and a member of methoxybenzenes.

Molecular structure

How much products actually contain

No product states its amount yet.

Of the products containing it, 8 list it before the 1% line and 0 after it (usually 1% or less).

Products using this ingredient

8 of 8 confirmed · likeliest to carry enough first

Definition

P-methoxyphenol is a member of phenols and a member of methoxybenzenes. It has a role as a metabolite.

Source: PubChem

US FDA substance register · UNII 6HT8U7K3AM · registered name Mequinol · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Slows spoilage by oxygenANTIOXIDANTReduces other ingredientsREDUCING

Safety & regulatory references

Banned
International fragrance standard (IFRA) · South Korea · Taiwan
Restricted or banned
South Korea · Taiwan
Restricted
United Kingdom

Source: IFRA fragrance standards · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · UK cosmetics regulations (OPSS)

ASEAN

  • Field of application and/or use : Artificial nail systems
  • Maximum authorised concentration in the finished cosmetic product : 0.02 % (After mixing for use)
  • Other limitations and requirements : Professional use only
  • Conditions of use and warning which must be printed on the labels : • For professional use only • Avoid skin contact • Read directions for use carefully

Canada

  • Conditions of Use by product type : Permitted only in nail products.
  • Maximum Concentration Permitted : 0.1% If hydroquinone and p-hydroxyanisole are used in the same product, the total concentration of the 2 ingredients may not exceed 0.1%
  • Warnings and Cautionary Statements: (to the effect of) : "Avoid skin contact", "Read directions carefully before using."

European Union

  • Product Type, body parts : Artificial nail systems
  • Maximum concentration in ready for use preparation : 0.02% (after mixing for use)
  • Other : Professional use
  • Wording of conditions of use and warnings : For professional use only Avoid skin contact Read directions for use carefully

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex III (restricted substances), entry 95 · maximum concentration 0.02% (after mixing for use) · applies to Artificial nail systems

Source: EU restricted substances (Annex III)

Restriction III/95 · Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Re-evaluation: p-Hydroxyanisole

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report: Amended Safety Assessment of p-Hydroxyanisole as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of p-Hydroxyanisole

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ヒドロキシアニソール: 本品は、フェノール(*)の誘導体であり、次の化学式で表される。

Source: JCIA labelling names (Japan)

JCIA labelling name p-ヒドロキシアニソール: 本品は、次の化学式で表される置換フェノール化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

P-HYDROXYANISOLEINCIp-하이드록시아니솔Korean label name (MFDS standard)Phenol, 4-methoxy-Synonymp-ヒドロキシアニソールJapanese labelling nameヒドロキシアニソールJapanese labelling name
CAS No.chemical registry number
150-76-5
EC No.EU chemical inventory number
205-769-8
DTXSIDUS EPA chemical ID
DTXSID4020828
DTXCIDUS EPA compound ID
DTXCID60828
IUPAC
4-Methoxyphenol
Molecular formula
C7H8O2
Molecular weight
124.139 g/mol

Measured properties

Appearance
Hydroquinone monomethyl ether appears as pink crystals or white waxy solid. (NTP, 1992) · Dry Powder, Large Crystals, Liquid
Odour
Odor of caramel and phenol
Boiling point
475 °F at 760 mmHg (NTP, 1992) · 253 °C
Melting point
126.5 °F (NTP, 1992) · 54 °C
Solubility
Soluble (NTP, 1992) · In water, 19,500 mg/L at 25 °C
Density
1.55 at 68 °F (NTP, 1992) - Denser than water, will sink · 1.55 at 20 °C/20 °C
Dissociation constant
pKa = 10.05 at 23 °C
Colour
Uncoloured to pale yellow
pH
5.6
Melting/freezing point
57.2 ℃
Initial boiling point and range
234 ℃
Flash point
90 ℃(1029hPa)
Flammability (solid, gas)
not flammable
Vapour pressure
1.3 ㎩ (25℃)
Water solubility
4 g/100㎖ (25℃)
Vapour density
4.3 (AIR=1)
Relative density
1.55 (20 °C)
n-Octanol/water partition coefficient (Kow)
1.23 (pH=7)
Auto-ignition temperature
421 ℃
Molecular weight
124.138

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 19 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

  • Lubricating agent5
  • Hydraulic fluids3
  • Stabilizing agent2
  • Intermediate2
  • Antioxidant2
  • Reducing agent2
  • Chemical reaction regulator1
  • Flavouring and nutrient1
1 other uses
  • Heat stabilizer1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

7 skin studies and 3 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 10 studies
  • Skin Sens. 1
    Skin Sensitization · Authoritative
  • Category 2
    Skin Irritation · Screening
  • Classification not possible
    Skin Sensitization · Screening
  • Moderate or Mild Irritation
    skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
  • Category 6.5B (Category 1)
    Skin Sensitization · Read Across
  • Skin sensitization - Category 1
    Skin Sensitization · Screening
  • Category 6.3A (Category 2)
    Skin Irritation · Read Across
  • Category 6.4A (Category 2A)
    Eye Irritation · Read Across
  • Eye Irrit. 2
    Eye Irritation · Authoritative
  • Category 2A
    Eye Irritation · Screening

Source: US EPA CompTox dashboard

Related literature

Linked databases 27