P-methoxyphenol is a member of phenols and a member of methoxybenzenes.
How much products actually contain
No product states its amount yet.
Of the products containing it, 8 list it before the 1% line and 0 after it (usually 1% or less).
Products using this ingredient
8 of 8 confirmed · likeliest to carry enough first
ORLYORLY Nail Tip Primer
ORLYORLY Nail Tip Primer - 0.6fl oz
CNDCND CND™ SHELLAC™ Gel Nail Polish - Cools
CNDCND CND™ SHELLAC™ Gel Nail Polish - Neutrals
CNDCND CND™ SHELLAC™ Gel Nail Polish - Nudes
CNDCND CND™ SHELLAC™ Gel Nail Polish - Pinks
CNDCND CND™ SHELLAC™ Gel Nail Polish - Reds
CNDCND CND™ SHELLAC™ Gel Nail Polish - Warms
Definition
P-methoxyphenol is a member of phenols and a member of methoxybenzenes. It has a role as a metabolite.
Source: PubChem
US FDA substance register · UNII 6HT8U7K3AM · registered name Mequinol · single chemical substance
Cosmetic roles
Safety & regulatory references
- Banned
- International fragrance standard (IFRA) · South Korea · Taiwan
- Restricted or banned
- South Korea · Taiwan
- Restricted
- United Kingdom
Source: IFRA fragrance standards · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · UK cosmetics regulations (OPSS)
ASEAN
- Field of application and/or use : Artificial nail systems
- Maximum authorised concentration in the finished cosmetic product : 0.02 % (After mixing for use)
- Other limitations and requirements : Professional use only
- Conditions of use and warning which must be printed on the labels : • For professional use only • Avoid skin contact • Read directions for use carefully
Canada
- Conditions of Use by product type : Permitted only in nail products.
- Maximum Concentration Permitted : 0.1% If hydroquinone and p-hydroxyanisole are used in the same product, the total concentration of the 2 ingredients may not exceed 0.1%
- Warnings and Cautionary Statements: (to the effect of) : "Avoid skin contact", "Read directions carefully before using."
European Union
- Product Type, body parts : Artificial nail systems
- Maximum concentration in ready for use preparation : 0.02% (after mixing for use)
- Other : Professional use
- Wording of conditions of use and warnings : For professional use only Avoid skin contact Read directions for use carefully
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex III (restricted substances), entry 95 · maximum concentration 0.02% (after mixing for use) · applies to Artificial nail systems
Restriction III/95 · Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Re-evaluation: p-Hydroxyanisole
Reviewed by CIR: Final Report: Amended Safety Assessment of p-Hydroxyanisole as Used in Cosmetics
Reviewed by CIR: Final Report on the Safety Assessment of p-Hydroxyanisole
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ヒドロキシアニソール: 本品は、フェノール(*)の誘導体であり、次の化学式で表される。
Source: JCIA labelling names (Japan)
JCIA labelling name p-ヒドロキシアニソール: 本品は、次の化学式で表される置換フェノール化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 150-76-5
- EC No.EU chemical inventory number
- 205-769-8
- DTXSIDUS EPA chemical ID
- DTXSID4020828
- DTXCIDUS EPA compound ID
- DTXCID60828
- IUPAC
- 4-Methoxyphenol
- Molecular formula
- C7H8O2
- Molecular weight
- 124.139 g/mol
Measured properties
- Appearance
- Hydroquinone monomethyl ether appears as pink crystals or white waxy solid. (NTP, 1992) · Dry Powder, Large Crystals, Liquid
- Odour
- Odor of caramel and phenol
- Boiling point
- 475 °F at 760 mmHg (NTP, 1992) · 253 °C
- Melting point
- 126.5 °F (NTP, 1992) · 54 °C
- Solubility
- Soluble (NTP, 1992) · In water, 19,500 mg/L at 25 °C
- Density
- 1.55 at 68 °F (NTP, 1992) - Denser than water, will sink · 1.55 at 20 °C/20 °C
- Dissociation constant
- pKa = 10.05 at 23 °C
- Colour
- Uncoloured to pale yellow
- pH
- 5.6
- Melting/freezing point
- 57.2 ℃
- Initial boiling point and range
- 234 ℃
- Flash point
- 90 ℃(1029hPa)
- Flammability (solid, gas)
- not flammable
- Vapour pressure
- 1.3 ㎩ (25℃)
- Water solubility
- 4 g/100㎖ (25℃)
- Vapour density
- 4.3 (AIR=1)
- Relative density
- 1.55 (20 °C)
- n-Octanol/water partition coefficient (Kow)
- 1.23 (pH=7)
- Auto-ignition temperature
- 421 ℃
- Molecular weight
- 124.138
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 19 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Lubricating agent5
- Hydraulic fluids3
- Stabilizing agent2
- Intermediate2
- Antioxidant2
- Reducing agent2
- Chemical reaction regulator1
- Flavouring and nutrient1
1 other uses
- Heat stabilizer1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
7 skin studies and 3 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 10 studies
- Skin Sens. 1
Skin Sensitization · Authoritative - Category 2
Skin Irritation · Screening - Classification not possible
Skin Sensitization · Screening - Moderate or Mild Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Skin sensitization - Category 1
Skin Sensitization · Screening - Category 6.3A (Category 2)
Skin Irritation · Read Across - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Eye Irrit. 2
Eye Irritation · Authoritative - Category 2A
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
Linked databases 27
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU restricted substances (Annex III)
- Health Canada Cosmetic Ingredient Hotlist
- IFRA fragrance standards
- JCIA labelling names (Japan)
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem 2
- Taiwan FDA cosmetic ingredients
- Tlooto literature search 2
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3 4
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese