4-methylaminophenol is the phenol that is the N-methyl derivative of 4-aminophenol.
- Korean limit
- 0.68%
How much products actually contain
No product states its amount yet.
Of the products containing it, 0 list it before the 1% line and 1 after it (usually 1% or less).
Products using this ingredient
1 of 1 confirmed · likeliest to carry enough first
Definition
4-methylaminophenol is the phenol that is the N-methyl derivative of 4-aminophenol. It has a role as an allergen. It is functionally related to a 4-aminophenol.
Source: PubChem
US FDA substance register · UNII 11W1883EFB · registered name P-METHYLAMINOPHENOL · single chemical substance
Cosmetic roles
Safety & regulatory references
- Restricted
- South Korea · Taiwan · United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · Taiwan FDA cosmetic regulations · UK cosmetics regulations (OPSS)
ASEAN
- Field of application and/or use : Hair dye substance in oxidative hair dye products. Use for dyeing eyelashes and eyebrows is not permitted.
- Other limitations and requirements : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.68 % (as sulphate) • Do not use with nitrosating systems • Maximum nitrosamine content: 50 μg/kg • Keep in nitrite-free containers The direction for use “wear suitable gloves” must be included in label or leaflet text.
- Conditions of use and warning which must be printed on the labels : The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past (a) and (b) Do not use to dye eyelashes or eyebrows
China
- Maximum concentration : 0.68%
European Union
- Product Type, body parts : Hair dye in oxidative hair dye products
- Other : Afther mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0,68% (as sulphate) - Do not use with nitrosating agents - Maximum nitrosamine content: 50 microgram/Kg - Keep in nitrite-free containers
- Wording of conditions of use and warnings : Hair colourants can cause severe allergic reactions
Source: MFDS (Korea) cosmetic regulatory information
Restriction III/223
Source: EU CosIng ingredient list
Restriction III/223 · Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Final Amended Report on the Safety Assessment of p-Methylaminophenol Sulfate and p-Methylaminophenol
Reviewed by CIR: Final Report on the Safety Assessment of p-Methylaminophenol Sulfate
Reviewed by CIR: Insufficient Data Announcement: Safety Assessment of p-Methylaminophenol andp-Methylaminophenol Sulfate as Used in Cosmetics
CIR reviewed this ingredient and flagged its status as: Insufficient Data Announcement: Safety Assessment of p-Methylaminophenol andp-Methylaminophenol Sulfate as Used in Cosmetics (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 150-75-4
- EC No.EU chemical inventory number
- 205-768-2
- DTXSIDUS EPA chemical ID
- DTXSID8043783
- DTXCIDUS EPA compound ID
- DTXCID6023783
- IUPAC
- 4-(Methylamino)phenol
- Molecular formula
- C7H9NO
- Molecular weight
- 123.155 g/mol
Measured properties
- Appearance
- solid
- Melting/freezing point
- 87
- Initial boiling point and range
- 209~211 ℃ (1.6 kPa)
- Vapour pressure
- 0.00307 ㎜Hg ((25℃))
- Water solubility
- 1.17 g/100㎖ ((25℃))
- n-Octanol/water partition coefficient (Kow)
- 0.79
- Molecular weight
- 123.15
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Dye2
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- SkinSens1
Skin Sensitization · QSAR Predicted - SkinIrr2
Skin Irritation · QSAR Predicted
Source: US EPA CompTox dashboard
Related literature
Linked databases 24
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2 3
- EU Cosmetics Regulation
- EU SCCS safety opinions
- Korea Cosmetic Association ingredient dictionary 2
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- PubChem
- Taiwan FDA cosmetic ingredients
- Taiwan FDA cosmetic regulations
- Tlooto literature search 2
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3 4 5 6 7
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata